{"entity": "publication", "iuid": "7e153160ba8d47d1845a45da018306b0", "timestamp": "2026-09-30T02:26:55.812Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7e153160ba8d47d1845a45da018306b0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7e153160ba8d47d1845a45da018306b0"}}, "title": "Brain-region-specific lipid dysregulation in L-DOPA-induced dyskinesia in a primate model of Parkinson's disease.", "authors": [{"family": "Kaya", "given": "Ibrahim", "initials": "I"}, {"family": "Vallianatou", "given": "Theodosia", "initials": "T"}, {"family": "Nilsson", "given": "Anna", "initials": "A"}, {"family": "Bj\u00e4rterot", "given": "Patrik", "initials": "P"}, {"family": "Shariatgorji", "given": "Reza", "initials": "R"}, {"family": "Svenningsson", "given": "Per", "initials": "P"}, {"family": "Bezard", "given": "Erwan", "initials": "E"}, {"family": "Andr\u00e9n", "given": "Per E", "initials": "PE"}], "type": "journal article", "published": "2025-08-23", "journal": {"title": "NPJ Parkinsons Dis", "issn": "2373-8057", "volume": "11", "issue": "1", "pages": "258", "issn-l": null}, "abstract": "L-DOPA-induced dyskinesia (LID) is a significant and treatment-limiting complication in Parkinson's disease (PD) therapy, yet its mechanisms remain poorly understood. We used high-resolution mass spectrometry imaging to map brain-region-specific alterations of glycerophospholipids and sphingolipids in a female macaque model of PD with and without LID following chronic L-DOPA treatment. LID was associated with depletion of antioxidant plasmalogen phosphatidylcholines in the globus pallidus interna, claustrum, and precentral gyrus-regions critical for motor function-and elevations of polyunsaturated fatty acid-containing glycerophospholipids, indicative of increased membrane fluidity. This lipid profile differed from similarly treated non-dyskinetic animals, suggesting lipid composition mediates differential susceptibility to LID. Lipid alterations correlated strongly with dyskinesia severity, dopamine, and L-DOPA concentrations, supporting a mechanistic link between lipid metabolism, neurotransmitter dysregulation, and LID. This comprehensive spatial lipidomic analysis identifies region-specific lipid dysregulation as a novel aspect of LID pathology, highlighting lipid pathways as potential therapeutic targets for mitigating dyskinesia.", "doi": "10.1038/s41531-025-01109-6", "pmid": "40849420", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12374971"}, {"db": "pii", "key": "10.1038/s41531-025-01109-6"}], "notes": [], "created": "2026-09-23T11:35:40.389Z", "modified": "2026-09-23T11:35:40.422Z"}