{"entity": "publication", "iuid": "7d5fdb8862f84252881c36e086f86581", "timestamp": "2026-09-08T10:05:44.562Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7d5fdb8862f84252881c36e086f86581.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7d5fdb8862f84252881c36e086f86581"}}, "title": "Human cytomegalovirus replication induces endothelial cell interleukin-11.", "authors": [{"family": "Gustafsson", "given": "K L R", "initials": "KLR"}, {"family": "Renn\u00e9", "given": "T", "initials": "T"}, {"family": "S\u00f6derberg-Naucler", "given": "C", "initials": "C"}, {"family": "Butler", "given": "L M", "initials": "LM"}], "type": "journal article", "published": "2018-11-00", "journal": {"title": "Cytokine", "issn": "1096-0023", "volume": "111", "pages": "563-566", "issn-l": "1043-4666"}, "abstract": "Endothelial cells (EC) are critical sites of human cytomegalovirus (hCMV) infection in vivo. Infection can induce the production of various EC cytokines, such as interleukin (IL-)6, which can have autocrine and/or paracrine effector functions. Here, we report that hCMV induces the production of EC IL-11, a relatively understudied member of the IL-6-type cytokine family. We detail temporal EC IL-11 translation and protein secretion dynamics in response to hCMV infection, and reveal distinct differences compared to EC IL-6. Viral replication had markedly opposing effects on the regulation of these closely related cytokines, representing a major driving force behind IL-11 production, whilst concurrently suppressing IL-6 expression. This is the first report of any biological agent that stimulates EC IL-11 production.", "doi": "10.1016/j.cyto.2018.05.018", "pmid": "29807687", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6299253"}, {"db": "pii", "key": "S1043-4666(18)30217-5"}], "notes": [], "created": "2026-08-21T11:17:46.496Z", "modified": "2026-08-21T11:17:46.508Z"}