{"entity": "publication", "iuid": "7a9e2a0e40e24344bad397c54a74123a", "timestamp": "2026-09-23T18:55:46.867Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7a9e2a0e40e24344bad397c54a74123a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7a9e2a0e40e24344bad397c54a74123a"}}, "title": "Identification of a discrete subpopulation of spinal cord ependymal cells with neural stem cell properties.", "authors": [{"family": "Stenudd", "given": "Moa", "initials": "M"}, {"family": "Sabelstr\u00f6m", "given": "Hanna", "initials": "H"}, {"family": "Llorens-Bobadilla", "given": "Enric", "initials": "E", "orcid": "0000-0002-7891-1272", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/796c6813bb64461485d5e0c966d46547.json"}}, {"family": "Zamboni", "given": "Margherita", "initials": "M", "orcid": "0000-0003-0664-4707", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dd167b1cb344898bccd0d60315db61c.json"}}, {"family": "Blom", "given": "Hans", "initials": "H"}, {"family": "Brismar", "given": "Hjalmar", "initials": "H", "orcid": "0000-0003-0578-4003", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/04321d9fb805493db538489927a42c8f.json"}}, {"family": "Zhang", "given": "Shupei", "initials": "S"}, {"family": "Basak", "given": "Onur", "initials": "O"}, {"family": "Clevers", "given": "Hans", "initials": "H", "orcid": "0000-0002-3077-5582", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1064100a57194938b25d307e5f069b20.json"}}, {"family": "G\u00f6ritz", "given": "Christian", "initials": "C", "orcid": "0000-0003-0799-766X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e2cb28cab7a447cdb6a627d59ea5f562.json"}}, {"family": "Barnab\u00e9-Heider", "given": "Fanie", "initials": "F"}, {"family": "Fris\u00e9n", "given": "Jonas", "initials": "J", "orcid": "0000-0001-5819-458X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c428941167b42c495b9fcdb6eb85729.json"}}], "type": "journal article", "published": "2022-03-01", "journal": {"title": "Cell Reports", "issn": "2211-1247", "volume": "38", "issue": "9", "pages": "110440", "issn-l": null}, "abstract": "Spinal cord ependymal cells display neural stem cell properties in vitro and generate scar-forming astrocytes and remyelinating oligodendrocytes after injury. We report that ependymal cells are functionally heterogeneous and identify a small subpopulation (8% of ependymal cells and 0.1% of all cells in a spinal cord segment), which we denote ependymal A (EpA) cells, that accounts for the in vitro stem cell potential in the adult spinal cord. After spinal cord injury, EpA cells undergo self-renewing cell division as they give rise to differentiated progeny. Single-cell transcriptome analysis revealed a loss of ependymal cell gene expression programs as EpA cells gained signaling entropy and dedifferentiated to a stem-cell-like transcriptional state after an injury. We conclude that EpA cells are highly differentiated cells that can revert to a stem cell state and constitute a therapeutic target for spinal cord repair.", "doi": "10.1016/j.celrep.2022.110440", "pmid": "35235796", "labels": [], "xrefs": [{"db": "pii", "key": "S2211-1247(22)00167-X"}], "notes": [], "created": "2026-09-23T08:44:04.526Z", "modified": "2026-09-23T14:50:42.296Z"}