{"entity": "publication", "iuid": "78bea92421d14ac295dd1175c9fd0cc8", "timestamp": "2026-09-25T23:05:06.828Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/78bea92421d14ac295dd1175c9fd0cc8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/78bea92421d14ac295dd1175c9fd0cc8"}}, "title": "Hydrazide-based reactive matrices for the sensitive detection of aldehydes and ketones by MALDI mass spectrometry imaging.", "authors": [{"family": "Lod\u00e9n", "given": "Henrik", "initials": "H", "orcid": "0000-0002-2416-5251", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8bfa3460823f470dbade7196519d2ae8.json"}}, {"family": "Schembri", "given": "Luke S", "initials": "LS", "orcid": "0000-0001-5588-1077", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a58aaafb4b1f411fac8203a2213c398f.json"}}, {"family": "Nilsson", "given": "Anna", "initials": "A"}, {"family": "Kaya", "given": "Ibrahim", "initials": "I"}, {"family": "Shariatgorji", "given": "Reza", "initials": "R"}, {"family": "Odell", "given": "Luke R", "initials": "LR", "orcid": "0000-0001-7658-5103", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49395660c6af4fce9ad0f7f8fc793744.json"}}, {"family": "Andr\u00e9n", "given": "Per E", "initials": "PE", "orcid": "0000-0002-4062-7743", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1dd27e8b238475383983480e10099f6.json"}}], "type": "journal article", "published": "2024-08-22", "journal": {"title": "Chem. Commun. (Camb.)", "issn": "1364-548X", "volume": "60", "issue": "69", "pages": "9238-9241", "issn-l": "1359-7345"}, "abstract": "A one-step, on-tissue chemical derivatisation method for MALDI mass spectrometry imaging was found to improve the detectability of aldehydes and ketones by charge-tagging. The developed reactive matrices, containing a UV-chromophore, ionisable moiety and hydrazide group, showed an equal or higher detection efficiency than Girard's reagent P, enabling improved imaging of brain metabolites without the need for additional co-matrices.", "doi": "10.1039/d4cc02475c", "pmid": "39114958", "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T12:29:39.709Z", "modified": "2026-09-23T12:29:39.767Z"}