{"entity": "publication", "iuid": "760715ec8ba64b92b62e387fb3802566", "timestamp": "2026-09-24T14:46:18.852Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/760715ec8ba64b92b62e387fb3802566.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/760715ec8ba64b92b62e387fb3802566"}}, "title": "The \u03b3-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells.", "authors": [{"family": "Corvaisier", "given": "Matthieu", "initials": "M"}, {"family": "Zhou", "given": "Jingkai", "initials": "J"}, {"family": "Malycheva", "given": "Darina", "initials": "D"}, {"family": "Cornella", "given": "Nicola", "initials": "N"}, {"family": "Chioureas", "given": "Dimitrios", "initials": "D"}, {"family": "Gustafsson", "given": "Nina M S", "initials": "NMS", "orcid": "0000-0001-6401-0548", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc62b4a3a4e84fa0b8a9f10d88710ccb.json"}}, {"family": "Rossell\u00f3", "given": "Catalina Ana", "initials": "CA", "orcid": "0000-0002-8977-607X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ce8861028ae34bbba3849481b3317233.json"}}, {"family": "Ayora", "given": "Silvia", "initials": "S", "orcid": "0000-0003-3121-1786", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e9607d343694fd1affe59fc4883e0c0.json"}}, {"family": "Li", "given": "Tongbin", "initials": "T"}, {"family": "Ekstr\u00f6m-Holka", "given": "Kristina", "initials": "K"}, {"family": "Jirstr\u00f6m", "given": "Karin", "initials": "K"}, {"family": "Lindstr\u00f6m", "given": "Lisa", "initials": "L"}, {"family": "Alvarado-Kristensson", "given": "Maria", "initials": "M", "orcid": "0000-0003-0598-7986", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/896d06c420314ada9079d6cce91ebcd3.json"}}], "type": "journal article", "published": "2021-06-22", "journal": {"title": "Commun Biol", "issn": "2399-3642", "volume": "4", "issue": "1", "pages": "767", "issn-l": "2399-3642"}, "abstract": "Changes in the location of \u03b3-tubulin ensure cell survival and preserve genome integrity. We investigated whether the nuclear accumulation of \u03b3-tubulin facilitates the transport of proliferating cell nuclear antigen (PCNA) between the cytosolic and the nuclear compartment in mammalian cells. We found that the \u03b3-tubulin meshwork assists in the recruitment of PCNA to chromatin. Also, decreased levels of \u03b3-tubulin reduce the nuclear pool of PCNA. In addition, the \u03b3-tubulin C terminus encodes a PCNA-interacting peptide (PIP) motif, and a \u03b3-tubulin-PIP-mutant affects the nuclear accumulation of PCNA. In a cell-free system, PCNA and \u03b3-tubulin formed a complex. In tumors, there is a significant positive correlation between TUBG1 and PCNA expression. Thus, we report a novel mechanism that constitutes the basis for tumor growth by which the \u03b3-tubulin meshwork maintains indefinite proliferation by acting as an opportune scaffold for the transport of PCNA from the cytosol to the chromatin.", "doi": "10.1038/s42003-021-02280-1", "pmid": "34158617", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8219688"}, {"db": "pii", "key": "10.1038/s42003-021-02280-1"}], "notes": [], "created": "2026-09-23T11:10:24.539Z", "modified": "2026-09-23T11:10:24.682Z"}