{"entity": "publication", "iuid": "757161ddbf6a423391d571dd44146efc", "timestamp": "2026-08-22T06:57:03.203Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/757161ddbf6a423391d571dd44146efc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/757161ddbf6a423391d571dd44146efc"}}, "title": "PD-1 expression on mouse intratumoral NK cells and its effects on NK cell phenotype.", "authors": [{"family": "Wagner", "given": "Arnika K", "initials": "AK"}, {"family": "Kadri", "given": "Nadir", "initials": "N"}, {"family": "Tibbitt", "given": "Chris", "initials": "C"}, {"family": "van de Ven", "given": "Koen", "initials": "K"}, {"family": "Bagawath-Singh", "given": "Sunitha", "initials": "S"}, {"family": "Oliinyk", "given": "Denys", "initials": "D"}, {"family": "LeGresley", "given": "Eric", "initials": "E"}, {"family": "Campbell", "given": "Nicole", "initials": "N"}, {"family": "Trittel", "given": "Stephanie", "initials": "S"}, {"family": "Riese", "given": "Peggy", "initials": "P"}, {"family": "Ribacke", "given": "Ulf", "initials": "U"}, {"family": "Sandalova", "given": "Tatyana", "initials": "T"}, {"family": "Achour", "given": "Adnane", "initials": "A"}, {"family": "K\u00e4rre", "given": "Klas", "initials": "K"}, {"family": "Chambers", "given": "Benedict J", "initials": "BJ"}], "type": "journal article", "published": "2022-10-21", "journal": {"title": "iScience", "issn": "2589-0042", "volume": "25", "issue": "10", "pages": "105137", "issn-l": null}, "abstract": "Although PD-1 was shown to be a hallmark of T cells exhaustion, controversial studies have been reported on the role of PD-1 on NK cells. Here, we found by flow cytometry and single cell RNA sequencing analysis that PD-1 can be expressed on MHC class I-deficient tumor-infiltrating NK cells in vivo. We also demonstrate distinct alterations in the phenotype of PD-1-deficient NK cells and a more mature phenotype which might reduce their capacity to migrate and kill in vivo. Tumor-infiltrating NK cells that express PD-1 were highly associated with the expression of CXCR6. Furthermore, our results demonstrate that PD-L1 molecules in membranes of PD-1-deficient NK cells migrate faster than in NK cells from wild-type mice, suggesting that PD-1 and PD-L1 form cis interactions with each other on NK cells. These data demonstrate that there may be a role for the PD-1/PD-L1 axis in tumor-infiltrating NK cells in vivo.", "doi": "10.1016/j.isci.2022.105137", "pmid": "36185379", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9523278"}, {"db": "pii", "key": "S2589-0042(22)01409-2"}], "notes": [], "created": "2026-08-20T07:57:50.439Z", "modified": "2026-08-20T07:57:50.451Z"}