{"entity": "publication", "iuid": "7470638ba3464d1ca47e649bd92fc65a", "timestamp": "2026-08-22T07:48:01.167Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7470638ba3464d1ca47e649bd92fc65a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7470638ba3464d1ca47e649bd92fc65a"}}, "title": "Maintenance use of non-steroidal anti-inflammatory drugs and risk of gastrointestinal cancer in a nationwide population-based cohort study in Sweden.", "authors": [{"family": "Brusselaers", "given": "Nele", "initials": "N", "orcid": "0000-0003-0137-447X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/70d0a6a2f4eb4272be4865e7e369c0e9.json"}}, {"family": "Lagergren", "given": "Jesper", "initials": "J", "orcid": "0000-0002-5143-5448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22af2b7bdbc64885a7853f684001735b.json"}}], "type": "journal article", "published": "2018-07-07", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "8", "issue": "7", "pages": "e021869", "issn-l": "2044-6055"}, "abstract": "Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) are potential candidates for chemoprevention of gastrointestinal cancer. We aimed to assess the association between contemporary NSAID use (\u2265180 days) and gastrointestinal cancer.\n\nNationwide Swedish population-based cohort study (2005-2012).\n\nSweden PARTICIPANTS: All adults exposed to maintenance NSAIDs use (aspirin, n=783 870; unselective NSAIDs, n=566 209, selective cyclo-oxygenase (COX)-2 inhibitors, n=17 948) compared with the Swedish background population of the same age, sex and calendar period.\n\nThe risk of different gastrointestinal cancer types expressed as standardised incidence ratios (SIR) and 95% CIs, taking into account concurrent proton pump inhibitors (PPIs) and statins usage.\n\nThe SIR for gastrointestinal cancer for aspirin use was 1.02 (95% CI 1.00 to 1.04), with clearly reduced risk for long-term users (SIR=0.31, 95% CI 0.30 to 0.33 for 5.5-7.7 years), but an increased risk for short-term users (SIR=2.77, 95% CI 2.69 to 2.85), and stronger protective effect for low-dose aspirin (SIR=0.86, 95% CI 0.85 to 0.88). Users of non-selective NSAIDs showed an overall decreased risk of gastrointestinal cancer (SIR=0.79, 95% CI 0.77 to 0.82), in particular for cancer of the stomach, colorectum and oesophagus, and the SIRs were further decreased among long-term users. Users of selective COX-2 inhibitors showed a SIR=0.89 (95% CI 0.73 to 1.09) for gastrointestinal cancers. Both aspirin and unselective NSAIDs users who also were using PPIs, had higher risks for all gastrointestinal cancer types; and lower risk if using statins.\n\nLong-term use of (low-dose) aspirin and non-selective NSAIDs was associated with a decreased risk of all gastrointestinal cancer types.", "doi": "10.1136/bmjopen-2018-021869", "pmid": "29982219", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6042574"}, {"db": "pii", "key": "bmjopen-2018-021869"}], "notes": [], "created": "2026-08-21T12:26:21.858Z", "modified": "2026-08-21T12:26:21.922Z"}