{"entity": "publication", "iuid": "71d3b5a25ec54843b9ae941e60c4c633", "timestamp": "2026-09-25T23:40:38.858Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/71d3b5a25ec54843b9ae941e60c4c633.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/71d3b5a25ec54843b9ae941e60c4c633"}}, "title": "Patient-derived organoids in precision cancer medicine.", "authors": [{"family": "Tong", "given": "Le", "initials": "L"}, {"family": "Cui", "given": "Weiyingqi", "initials": "W"}, {"family": "Zhang", "given": "Boya", "initials": "B"}, {"family": "Fonseca", "given": "Pedro", "initials": "P"}, {"family": "Zhao", "given": "Qian", "initials": "Q"}, {"family": "Zhang", "given": "Ping", "initials": "P"}, {"family": "Xu", "given": "Beibei", "initials": "B"}, {"family": "Zhang", "given": "Qisi", "initials": "Q"}, {"family": "Li", "given": "Zhen", "initials": "Z"}, {"family": "Seashore-Ludlow", "given": "Brinton", "initials": "B"}, {"family": "Yang", "given": "Ying", "initials": "Y"}, {"family": "Si", "given": "Longlong", "initials": "L"}, {"family": "Lundqvist", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2024-11-08", "journal": {"title": "Med", "issn": "2666-6340", "volume": "5", "issue": "11", "pages": "1351-1377", "issn-l": null}, "abstract": "Organoids are three-dimensional (3D) cultures, normally derived from stem cells, that replicate the complex structure and function of human tissues. They offer a physiologically relevant model to address important questions in cancer research. The generation of patient-derived organoids (PDOs) from various human cancers allows for deeper insights into tumor heterogeneity and spatial organization. Additionally, interrogating non-tumor stromal cells increases the relevance in studying the tumor microenvironment, thereby enhancing the relevance of PDOs in personalized medicine. PDOs mark a significant advancement in cancer research and patient care, signifying a shift toward more innovative and patient-centric approaches. This review covers aspects of PDO cultures to address the modeling of the tumor microenvironment, including extracellular matrices, air-liquid interface and microfluidic cultures, and organ-on-chip. Specifically, the role of PDOs as preclinical models in gene editing, molecular profiling, drug testing, and biomarker discovery and their potential for guiding personalized treatment in clinical practice are discussed.", "doi": "10.1016/j.medj.2024.08.010", "pmid": "39341206", "labels": [], "xrefs": [{"db": "pii", "key": "S2666-6340(24)00343-X"}], "notes": [], "created": "2026-09-23T07:28:26.957Z", "modified": "2026-09-23T07:28:26.988Z"}