{"entity": "publication", "iuid": "6bd198b0eb0e44d1aba860f0b9da8560", "timestamp": "2026-09-23T15:30:40.443Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6bd198b0eb0e44d1aba860f0b9da8560.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6bd198b0eb0e44d1aba860f0b9da8560"}}, "title": "The landscape of viral associations in human cancers.", "authors": [{"family": "Zapatka", "given": "Marc", "initials": "M", "orcid": "0000-0001-8287-5967", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/530d4def196a4ea18cd6e6ffd022e05b.json"}}, {"family": "Borozan", "given": "Ivan", "initials": "I", "orcid": "0000-0002-3145-3550", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02e78d7d03ed4715800319a0229656af.json"}}, {"family": "Brewer", "given": "Daniel S", "initials": "DS", "orcid": "0000-0003-4753-9794", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2ac4c04ae81e4415bcfea82e7e16f2fd.json"}}, {"family": "Iskar", "given": "Murat", "initials": "M"}, {"family": "Grundhoff", "given": "Adam", "initials": "A", "orcid": "0000-0003-0940-7045", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/79b9064234af4ba8aa7bd5b2e799166d.json"}}, {"family": "Alawi", "given": "Malik", "initials": "M", "orcid": "0000-0002-5993-7709", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/624b91837b4f4fa1818fd5b58a13c4c4.json"}}, {"family": "Desai", "given": "Nikita", "initials": "N"}, {"family": "S\u00fcltmann", "given": "Holger", "initials": "H"}, {"family": "Moch", "given": "Holger", "initials": "H"}, {"family": "PCAWG Pathogens", "given": "", "initials": ""}, {"family": "Cooper", "given": "Colin S", "initials": "CS"}, {"family": "Eils", "given": "Roland", "initials": "R", "orcid": "0000-0002-0034-4036", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee7862faa48146e29390380c7b768dac.json"}}, {"family": "Ferretti", "given": "Vincent", "initials": "V"}, {"family": "Lichter", "given": "Peter", "initials": "P", "orcid": "0000-0002-2960-5279", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e2111252b5343e6b5779f1304754ff0.json"}}, {"family": "PCAWG Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2020-03-00", "journal": {"title": "Nat. Genet.", "issn": "1546-1718", "volume": "52", "issue": "3", "pages": "320-330", "issn-l": "1061-4036"}, "abstract": "Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and-for a subset-whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential viral pathogens using a consensus approach that integrated three independent pipelines. Viruses were detected in 382 genome and 68 transcriptome datasets. We found a high prevalence of known tumor-associated viruses such as Epstein-Barr virus (EBV), hepatitis B virus (HBV) and human papilloma virus (HPV; for example, HPV16 or HPV18). The study revealed significant exclusivity of HPV and driver mutations in head-and-neck cancer and the association of HPV with APOBEC mutational signatures, which suggests that impaired antiviral defense is a driving force in cervical, bladder and head-and-neck carcinoma. For HBV, HPV16, HPV18 and adeno-associated virus-2 (AAV2), viral integration was associated with local variations in genomic copy numbers. Integrations at the TERT promoter were associated with high telomerase expression evidently activating this tumor-driving process. High levels of endogenous retrovirus (ERV1) expression were linked to a worse survival outcome in patients with kidney cancer.", "doi": "10.1038/s41588-019-0558-9", "pmid": "32025001", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8076016"}, {"db": "pii", "key": "10.1038/s41588-019-0558-9"}], "notes": [], "created": "2026-09-23T06:34:38.903Z", "modified": "2026-09-23T06:34:39.159Z"}