{"entity": "publication", "iuid": "6b680093a3cb49cda0c9a98b06504990", "timestamp": "2026-08-20T20:46:30.563Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6b680093a3cb49cda0c9a98b06504990.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6b680093a3cb49cda0c9a98b06504990"}}, "title": "Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes.", "authors": [{"family": "You", "given": "Yuanyuan", "initials": "Y"}, {"family": "Dunst", "given": "Josefine", "initials": "J"}, {"family": "Ye", "given": "Kewei", "initials": "K"}, {"family": "Sandoz", "given": "Patrick A", "initials": "PA", "orcid": "0000-0002-8379-7267", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d309ec0cb74f41a49a18e226079e6787.json"}}, {"family": "Reinhardt", "given": "Annika", "initials": "A"}, {"family": "Sandrock", "given": "Inga", "initials": "I"}, {"family": "Comet", "given": "Natalia R", "initials": "NR"}, {"family": "Sarkar", "given": "Rupak Dey", "initials": "RD", "orcid": "0009-0008-0203-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/24869b9044774be6bde6090a2e2c27ed.json"}}, {"family": "Yang", "given": "Emily", "initials": "E", "orcid": "0000-0002-6028-2455", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d94a4017752b450c96df61ec726a0613.json"}}, {"family": "Duprez", "given": "Estelle", "initials": "E", "orcid": "0000-0003-3810-5740", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2b3b8efc080f49d8b3e02bf5a07b2409.json"}}, {"family": "Agudo", "given": "Judith", "initials": "J"}, {"family": "Brown", "given": "Brian D", "initials": "BD", "orcid": "0000-0002-3670-8778", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b871795458dc4bd8836af26e853fb34f.json"}}, {"family": "Utz", "given": "Paul J", "initials": "PJ", "orcid": "0000-0003-1181-1565", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7d6ff897a183439d8895f72eb18cfdb3.json"}}, {"family": "Kastenm\u00fcller", "given": "Wolfgang", "initials": "W", "orcid": "0000-0002-3835-1485", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5be40dc506934b74bc74acf292df18e2.json"}}, {"family": "Gerlach", "given": "Carmen", "initials": "C", "orcid": "0000-0001-7889-2393", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8053f26c59c24fe9b98ef54a2ba1b16b.json"}}, {"family": "Prinz", "given": "Immo", "initials": "I"}, {"family": "\u00d6nfelt", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0001-5178-7593", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b4b8fcbedb54e2ba38633687f417ae8.json"}}, {"family": "Kreslavsky", "given": "Taras", "initials": "T", "orcid": "0000-0002-6672-1914", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a81b55340f7c4eda9b079c0ddc182a6d.json"}}], "type": "journal article", "published": "2024-08-00", "journal": {"title": "Nat. Immunol.", "issn": "1529-2916", "volume": "25", "issue": "8", "pages": "1367-1382", "issn-l": "1529-2908"}, "abstract": "Upregulation of diverse self-antigens that constitute components of the inflammatory response overlaps spatially and temporally with the emergence of pathogen-derived foreign antigens. Therefore, discrimination between these inflammation-associated self-antigens and pathogen-derived molecules represents a unique challenge for the adaptive immune system. Here, we demonstrate that CD8+ T cell tolerance to T cell-derived inflammation-associated self-antigens is efficiently induced in the thymus and supported by redundancy in cell types expressing these molecules. In addition to thymic epithelial cells, this included thymic eosinophils and innate-like T cells, a population that expressed molecules characteristic for all major activated T cell subsets. We show that direct T cell-to-T cell antigen presentation by minute numbers of innate-like T cells was sufficient to eliminate autoreactive CD8+ thymocytes. Tolerance to such effector molecules was of critical importance, as its breach caused by decreased thymic abundance of a single model inflammation-associated self-antigen resulted in autoimmune elimination of an entire class of effector T cells.", "doi": "10.1038/s41590-024-01899-6", "pmid": "38992254", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11291280"}, {"db": "pii", "key": "10.1038/s41590-024-01899-6"}], "notes": [], "created": "2026-08-20T09:01:42.380Z", "modified": "2026-08-20T09:01:42.758Z"}