{"entity": "publication", "iuid": "64501b75dbca4a3fb9558e92f22f428a", "timestamp": "2026-08-22T06:55:31.278Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/64501b75dbca4a3fb9558e92f22f428a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/64501b75dbca4a3fb9558e92f22f428a"}}, "title": "Genetically Predicted Circulating Copper and Risk of Chronic Kidney Disease: A Mendelian Randomization Study.", "authors": [{"family": "Ahmad", "given": "Shafqat", "initials": "S"}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J"}, {"family": "Larsson", "given": "Susanna C", "initials": "SC", "orcid": "0000-0003-0118-0341", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32bbf6e5ec4343fda3f1f2d839f06c4e.json"}}], "type": "journal article", "published": "2022-01-25", "journal": {"title": "Nutrients", "issn": "2072-6643", "volume": "14", "issue": "3", "issn-l": "2072-6643"}, "abstract": "Elevated circulating copper levels have been associated with chronic kidney disease (CKD), kidney damage, and decline in kidney function. Using a two sample Mendelian randomization approach where copper-associated genetic variants were used as instrumental variables, genetically predicted higher circulating copper levels were associated with higher CKD prevalence (odds ratio 1.17; 95% confidence interval 1.04, 1.32; p-value = 0.009). There was suggestive evidence that genetically predicted higher copper was associated with a lower estimated glomerular filtration rate and a more rapid kidney damage decline. In conclusion, we observed that elevated circulating copper levels may be a causal risk factor for CKD.", "doi": "10.3390/nu14030509", "pmid": "35276868", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8840411"}, {"db": "pii", "key": "nu14030509"}], "notes": [], "created": "2026-08-21T13:04:31.124Z", "modified": "2026-08-21T13:04:31.217Z"}