{"entity": "publication", "iuid": "63ae9ad2a9de4b638f6deddc593a6251", "timestamp": "2026-09-24T02:37:10.772Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/63ae9ad2a9de4b638f6deddc593a6251.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/63ae9ad2a9de4b638f6deddc593a6251"}}, "title": "Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA-induced dyskinesia.", "authors": [{"family": "Fridjonsdottir", "given": "Elva", "initials": "E", "orcid": "0000-0002-3779-3556", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/749090040c9c451ba610b0e144fa75e7.json"}}, {"family": "Shariatgorji", "given": "Reza", "initials": "R", "orcid": "0000-0001-9484-0921", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76faa76e9dc445a3bbb1f470e9d33a23.json"}}, {"family": "Nilsson", "given": "Anna", "initials": "A", "orcid": "0000-0002-6183-6931", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d381828fd204a249e5b4df03e7497f6.json"}}, {"family": "Vallianatou", "given": "Theodosia", "initials": "T", "orcid": "0000-0002-1477-7756", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4374524ab2c14bd9ae46f904144dea63.json"}}, {"family": "Odell", "given": "Luke R", "initials": "LR", "orcid": "0000-0001-7658-5103", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49395660c6af4fce9ad0f7f8fc793744.json"}}, {"family": "Schembri", "given": "Luke S", "initials": "LS", "orcid": "0000-0001-5588-1077", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a58aaafb4b1f411fac8203a2213c398f.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "Fernagut", "given": "Pierre-Olivier", "initials": "PO", "orcid": "0000-0002-7737-5439", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2fdec2bbb6734de9b9926abdc0c583ac.json"}}, {"family": "Crossman", "given": "Alan R", "initials": "AR"}, {"family": "Bezard", "given": "Erwan", "initials": "E", "orcid": "0000-0002-0410-4638", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/92f25ac8ff1d46ce8b68fbd88cd36843.json"}}, {"family": "Andr\u00e9n", "given": "Per E", "initials": "PE", "orcid": "0000-0002-4062-7743", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1dd27e8b238475383983480e10099f6.json"}}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "7", "issue": "2", "issn-l": "2375-2548"}, "abstract": "l-DOPA treatment for Parkinson's disease frequently leads to dyskinesias, the pathophysiology of which is poorly understood. We used MALDI-MSI to map the distribution of l-DOPA and monoaminergic pathways in brains of dyskinetic and nondyskinetic primates. We report elevated levels of l-DOPA, and its metabolite 3-O-methyldopa, in all measured brain regions of dyskinetic animals and increases in dopamine and metabolites in all regions analyzed except the striatum. In dyskinesia, dopamine levels correlated well with l-DOPA levels in extrastriatal regions, such as hippocampus, amygdala, bed nucleus of the stria terminalis, and cortical areas, but not in the striatum. Our results demonstrate that l-DOPA-induced dyskinesia is linked to a dysregulation of l-DOPA metabolism throughout the brain. The inability of extrastriatal brain areas to regulate the formation of dopamine during l-DOPA treatment introduces the potential of dopamine or even l-DOPA itself to modulate neuronal signaling widely across the brain, resulting in unwanted side effects.", "doi": "10.1126/sciadv.abe5948", "pmid": "33523980", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7787486"}, {"db": "pii", "key": "7/2/eabe5948"}], "notes": [], "created": "2026-09-23T08:39:20.140Z", "modified": "2026-09-23T08:39:20.362Z"}