{"entity": "publication", "iuid": "62d23441b06c420ca6c7ec12e9055f95", "timestamp": "2026-08-26T22:47:26.391Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/62d23441b06c420ca6c7ec12e9055f95.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/62d23441b06c420ca6c7ec12e9055f95"}}, "title": "Cost-effectiveness analysis of repeated self-sampling for HPV testing in primary cervical screening: a randomized study.", "authors": [{"family": "Aarnio", "given": "Riina", "initials": "R", "orcid": "0000-0001-6752-531X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60c29c4a11e24b9b9263d5f50ff658be.json"}}, {"family": "\u00d6stensson", "given": "Ellinor", "initials": "E"}, {"family": "Olovsson", "given": "Matts", "initials": "M"}, {"family": "Gustavsson", "given": "Inger", "initials": "I"}, {"family": "Gyllensten", "given": "Ulf", "initials": "U"}], "type": "journal article", "published": "2020-07-13", "journal": {"title": "BMC Cancer", "issn": "1471-2407", "volume": "20", "issue": "1", "pages": "645", "issn-l": "1471-2407"}, "abstract": "Human papillomavirus (HPV) testing is recommended in primary cervical screening to improve cancer prevention. An advantage of HPV testing is that it can be performed on self-samples, which could increase population coverage and result in a more efficient strategy to identify women at risk of developing cervical cancer. Our objective was to assess whether repeated self-sampling for HPV testing is cost-effective in comparison with Pap smear cytology for detection of cervical intraepithelial neoplasia grade 2 or more (CIN2+) in increasing participation rate in primary cervical screening.\n\nA cost-effectiveness analysis (CEA) was performed on data from a previously published randomized clinical study including 36,390 women aged 30-49 years. Participants were randomized either to perform repeated self-sampling of vaginal fluid for HPV testing (n = 17,997, HPV self-sampling arm) or to midwife-collected Pap smears for cytological analysis (n = 18,393, Pap smear arm).\n\nSelf-sampling for HPV testing led to 1633 more screened women and 107 more histologically diagnosed CIN2+ at a lower cost vs. midwife-collected Pap smears (\u20ac 229,446 vs. \u20ac 782,772).\n\nThis study resulted in that repeated self-sampling for HPV testing increased participation and detection of CIN2+ at a lower cost than midwife-collected Pap smears in primary cervical screening. Offering women a home-based self-sampling may therefore be a more cost-effective alternative than clinic-based screening.\n\nNot registered since this trial is a secondary analysis of an earlier published study (Gustavsson et al., British journal of cancer. 118:896-904, 2018).", "doi": "10.1186/s12885-020-07085-9", "pmid": "32660432", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7359275"}, {"db": "pii", "key": "10.1186/s12885-020-07085-9"}], "notes": [], "created": "2026-08-21T12:38:49.140Z", "modified": "2026-08-21T12:38:49.182Z"}