{"entity": "publication", "iuid": "62b65b338e974d0b82eef298d4c72699", "timestamp": "2026-08-20T21:03:00.809Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/62b65b338e974d0b82eef298d4c72699.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/62b65b338e974d0b82eef298d4c72699"}}, "title": "Regio- and Stereoselective Synthesis of Allylic Spiroethers (Spirobenzofuranes) via an Intramolecular Mizoroki-Heck Reaction.", "authors": [{"family": "Adeyemi", "given": "Ahmed", "initials": "A"}, {"family": "Odell", "given": "Luke R", "initials": "LR", "orcid": "0000-0001-7658-5103", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49395660c6af4fce9ad0f7f8fc793744.json"}}, {"family": "Larhed", "given": "Mats", "initials": "M", "orcid": "0000-0001-6258-0635", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/225695195abc4233bd141e6858e72e7f.json"}}], "type": "journal article", "published": "2020-06-19", "journal": {"title": "J. Org. Chem.", "issn": "1520-6904", "volume": "85", "issue": "12", "pages": "7648-7657", "issn-l": "0022-3263"}, "abstract": "The palladium(0)-catalyzed intramolecular annulation of 12 1,3-disubstituted cyclopentenes, derived from (+)-vince lactam, resulted in 5-exo cyclizations which furnished a series of 2,5-dimethyl-1-((3R,4'S)-2H-spiro[benzofuran-3,1'-cyclopentan]-2'-en-4'-yl)-1H-pyrroles in excellent diastereoselectivities and useful isolated yields. The double bond migration process that followed the arylpalladium insertion was controlled by a fine-tuning of the reaction system, which provided regioselectivities of up to 98:2. The selective Mizoroki-Heck reaction was used as the key transformation for preparing two new spirocyclic monoprotected amino acids as single stereoisomers.", "doi": "10.1021/acs.joc.9b03329", "pmid": "32083867", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T08:10:58.675Z", "modified": "2026-08-20T08:10:58.752Z"}