{"entity": "publication", "iuid": "5fef08eda5114edea2d9e41d5d5c3d56", "timestamp": "2026-09-06T11:03:03.016Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5fef08eda5114edea2d9e41d5d5c3d56.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5fef08eda5114edea2d9e41d5d5c3d56"}}, "title": "Prevalence of the human papillomavirus (HPV) types among cervical dysplasia women attending a gynaecological clinic in Sweden.", "authors": [{"family": "Garc\u00eda", "given": "Fabricio Romero", "initials": "FR"}, {"family": "Norenhag", "given": "Johanna", "initials": "J"}, {"family": "Edfeldt", "given": "Gabriella", "initials": "G"}, {"family": "Cheng", "given": "Liqin", "initials": "L"}, {"family": "Hugerth", "given": "Luisa Warchavchik", "initials": "LW"}, {"family": "Pennhag", "given": "Alexandra A L", "initials": "AAL"}, {"family": "Schuppe-Koistinen", "given": "Ina", "initials": "I"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Olovsson", "given": "Matts", "initials": "M"}, {"family": "Du", "given": "Juan", "initials": "J"}], "type": "journal article", "published": "2023-08-22", "journal": {"title": "BJC Rep", "issn": "2731-9377", "volume": "1", "issue": "1", "pages": "11", "issn-l": null}, "abstract": "Human papillomavirus (HPV) is the main cause of cervical cancer. HPV-vaccines have led to a significant decrease in HPV-infections and related cancer cases. The estimation of the current HPV-prevalence and distribution of different HPV-types among women with cervical dysplasia is important for the future vaccination strategy.\n\nBy using a multiplexed bead-based immunoassay, we revealed the prevalence of 27 HPV-types in 168 dysplasia women aged 21-70 from Uppsala University hospital, Sweden.\n\nThe prevalence of HPV in low-and high-grade squamous intraepithelial lesions (LSIL and HSIL, respectively) were 56.3% and 76.7%, respectively. The oncogenic HPV-types constituted 80.0%, and 97.1% among the HPV-positive LSIL and HSIL-groups, respectively, with HPV16 as the most prevalent type. We found a reduction in oncogenic HPV-types covered by the bi- and quadrivalent vaccines in the vaccinated HSIL-group, suggesting the effectiveness of the HPV-vaccine in preventing dysplasia caused by the covered HPV-types. Oncogenic HPV-types 39 and 59, not covered by any current vaccine have an important prevalence among patients with cervical dysplasia.\n\nOncogenic-HPV-types are highly prevalent among women with HSIL. The current vaccine presents effectiveness for reducing the covered HPV-types among dysplasia patients.", "doi": "10.1038/s44276-023-00012-y", "pmid": "39516656", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11524002"}, {"db": "pii", "key": "10.1038/s44276-023-00012-y"}], "notes": [], "created": "2026-08-20T09:26:34.298Z", "modified": "2026-08-20T09:26:34.367Z"}