{"entity": "publication", "iuid": "5e0e17d959554786ad6368f8283e32d2", "timestamp": "2026-09-23T22:45:39.649Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5e0e17d959554786ad6368f8283e32d2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5e0e17d959554786ad6368f8283e32d2"}}, "title": "High throughput barcoding method for genome-scale phasing.", "authors": [{"family": "Redin", "given": "David", "initials": "D"}, {"family": "Frick", "given": "Tobias", "initials": "T"}, {"family": "Aghelpasand", "given": "Hooman", "initials": "H"}, {"family": "K\u00e4ller", "given": "Max", "initials": "M", "orcid": "0000-0001-6813-3051", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bbbf41bd13c347898cc7fa0cedd4e6b2.json"}}, {"family": "Borgstr\u00f6m", "given": "Erik", "initials": "E"}, {"family": "Olsen", "given": "Remi-Andre", "initials": "RA"}, {"family": "Ahmadian", "given": "Afshin", "initials": "A"}], "type": "journal article", "published": "2019-12-02", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "9", "issue": "1", "pages": "18116", "issn-l": "2045-2322"}, "abstract": "The future of human genomics is one that seeks to resolve the entirety of genetic variation through sequencing. The prospect of utilizing genomics for medical purposes require cost-efficient and accurate base calling, long-range haplotyping capability, and reliable calling of structural variants. Short-read sequencing has lead the development towards such a future but has struggled to meet the latter two of these needs. To address this limitation, we developed a technology that preserves the molecular origin of short sequencing reads, with an insignificant increase to sequencing costs. We demonstrate a novel library preparation method for high throughput barcoding of short reads where millions of random barcodes can be used to reconstruct megabase-scale phase blocks.", "doi": "10.1038/s41598-019-54446-x", "pmid": "31792271", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6889410"}, {"db": "pii", "key": "10.1038/s41598-019-54446-x"}], "notes": [], "created": "2026-09-23T10:57:25.414Z", "modified": "2026-09-23T10:57:25.491Z"}