{"entity": "publication", "iuid": "5691923abb824a57b45de403acb6d578", "timestamp": "2026-09-30T00:55:54.392Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5691923abb824a57b45de403acb6d578.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5691923abb824a57b45de403acb6d578"}}, "title": "Genome-wide association study of liver enzyme elevation in an extended cohort of rheumatoid arthritis patients starting low-dose methotrexate.", "authors": [{"family": "Cavalli", "given": "Marco", "initials": "M", "orcid": "0000-0003-1143-1431", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c3104b875f2e459093b1e468ba4af556.json"}}, {"family": "Eriksson", "given": "Niclas", "initials": "N", "orcid": "0000-0002-2152-4343", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c2aa082be0ca4fe88eba557bc92a735a.json"}}, {"family": "Sundbaum", "given": "Johanna Karlsson", "initials": "JK", "orcid": "0000-0001-5313-7981", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ae6b28953794a7482d3f9bff2074aaf.json"}}, {"family": "Wallenberg", "given": "Matilda", "initials": "M"}, {"family": "Kohnke", "given": "Hugo", "initials": "H"}, {"family": "Baecklund", "given": "Eva", "initials": "E"}, {"family": "Hallberg", "given": "P\u00e4r", "initials": "P", "orcid": "0000-0003-3465-3280", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cbedc282a27446f7992646cf3608c36f.json"}}, {"family": "Wadelius", "given": "Mia", "initials": "M", "orcid": "0000-0002-6368-2622", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1a663f51c194a8f8060b6fa54f11ac6.json"}}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "Pharmacogenomics", "issn": "1744-8042", "volume": "23", "issue": "15", "pages": "813-820", "issn-l": "1462-2416"}, "abstract": "Aim: A follow-up genome-wide association study (GWAS) in an extended cohort of rheumatoid arthritis (RA) patients starting low-dose methotrexate (MTX) treatment was performed to identify further genetic variants associated with alanine aminotransferase (ALT) elevation. Patients & methods: A GWAS was performed on 346 RA patients. Two outcomes within the first 6 months of MTX treatment were assessed: ALT >1.5-times the upper level of normal (ULN) and maximum level of ALT. Results: SPATA9 (rs72783407) was significantly associated with maximum level of ALT (p = 2.58 \u00d7 10-8) and PLCG2 (rs60427389) was tentatively associated with ALT >1.5 \u00d7 ULN. Conclusion: Associations with SNPs in genes related to male fertility (SPATA9) and inflammatory processes (PLCG2) were identified.", "doi": "10.2217/pgs-2022-0074", "pmid": "36070248", "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T12:50:43.442Z", "modified": "2026-09-23T12:50:43.530Z"}