{"entity": "publication", "iuid": "4e71edfe55b041cdbc2418c683b59375", "timestamp": "2026-09-26T23:30:35.763Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4e71edfe55b041cdbc2418c683b59375.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4e71edfe55b041cdbc2418c683b59375"}}, "title": "No association between coffee consumption and risk of atrial fibrillation: A Mendelian randomization study.", "authors": [{"family": "Yuan", "given": "Shuai", "initials": "S"}, {"family": "Larsson", "given": "Susanna C", "initials": "SC"}], "type": "journal article", "published": "2019-11-00", "journal": {"title": "Nutr Metab Cardiovasc Dis", "issn": "1590-3729", "volume": "29", "issue": "11", "pages": "1185-1188", "issn-l": null}, "abstract": "Some observational studies have found that habitual coffee and caffeine consumption might reduce the risk of atrial fibrillation (AF). We conducted a two-sample Mendelian randomization study to explore the potential association between coffee consumption and AF.\n\nThis study was based on summary-level data from the Atrial Fibrillation Consortium, including 588 190 individuals (65 446 cases and 522 744 non-cases). Nine single-nucleotide polymorphisms associated with coffee consumption at significance level of P < 5 \u00d7 10-8 were used as instrumental variables and were obtained from a genome-wide association study that included up to 375 833 individuals. The odds ratio of AF per genetically-predicted 50% increase of coffee consumption was 0.98 (95% confidence interval, 0.88, 1.10; P = 0.80) in the standard inverse-variance weighted analysis. Results were consistent in sensitivity analyses using the weighted median and MR-Egger methods, and no directional pleiotropy (P = 0.37) was observed. Moreover, complementary analyses that separated the coffee-related single-nucleotide polymorphisms based on their association with blood levels of caffeine metabolites (lower, higher, unrelated or unknown association) revealed no association with AF.\n\nThis study does not support a causal association between habitual coffee consumption and risk of AF.", "doi": "10.1016/j.numecd.2019.07.015", "pmid": "31558414", "labels": [], "xrefs": [{"db": "pii", "key": "S0939-4753(19)30283-2"}], "notes": [], "created": "2026-09-23T10:05:17.907Z", "modified": "2026-09-23T10:43:57.603Z"}