{"entity": "publication", "iuid": "4cc87003693241acbf1da7cdd11e9e39", "timestamp": "2026-08-22T08:31:56.049Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4cc87003693241acbf1da7cdd11e9e39.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4cc87003693241acbf1da7cdd11e9e39"}}, "title": "Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy.", "authors": [{"family": "Ollila", "given": "Hanna M", "initials": "HM"}, {"family": "Sharon", "given": "Eilon", "initials": "E", "orcid": "0000-0002-1262-350X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5be192899d6640a88115567ed64e0d68.json"}}, {"family": "Lin", "given": "Ling", "initials": "L"}, {"family": "Sinnott-Armstrong", "given": "Nasa", "initials": "N", "orcid": "0000-0003-4490-0601", "researcher": {"href": 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{"href": "https://publications-affiliated.scilifelab.se/researcher/025f73f8c09941029d38a7715057dfb1.json"}}, {"family": "Rueger", "given": "Sina", "initials": "S", "orcid": "0000-0003-2848-9242", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/68de842e81724860931b57d64f7e7b48.json"}}, {"family": "Winkelmann", "given": "Juliane", "initials": "J", "orcid": "0000-0002-3074-599X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/82a21dd6c23144bf9e9883aa4a816056.json"}}, {"family": "Miyagawa", "given": "Taku", "initials": "T"}, {"family": "Toyoda", "given": "Hiromi", "initials": "H"}, {"family": "Khor", "given": "Seik-Soon", "initials": "SS", "orcid": "0000-0002-6809-4731", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/71176d5d4e834c25ae12607d0f5fe803.json"}}, {"family": "Shimada", "given": "Mihoko", "initials": "M"}, {"family": "Tokunaga", "given": "Katsushi", "initials": "K"}, {"family": "Rivas", "given": "Manuel", "initials": "M", "orcid": "0000-0003-1457-9925", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d7f17209d4774b408500d9ada91c751a.json"}}, {"family": "Pritchard", "given": "Jonathan K", "initials": "JK"}, {"family": "Risch", "given": "Neil", "initials": "N", "orcid": "0000-0002-4126-2061", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa37ed94386d431ab20096649e10ce2e.json"}}, {"family": "Kutalik", "given": "Zoltan", "initials": "Z", "orcid": "0000-0001-8285-7523", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e566b994d65a4365b224cd4ae369827a.json"}}, {"family": "O'Hara", "given": "Ruth", "initials": "R"}, {"family": "Hallmayer", "given": "Joachim", "initials": "J"}, {"family": "Ye", "given": "Chun Jimmie", "initials": "CJ", "orcid": "0000-0001-6560-3783", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/07981b1799a14491b8123d1f9ab999f8.json"}}, {"family": "Mignot", "given": "Emmanuel J", "initials": "EJ", "orcid": "0000-0002-6928-5310", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/08d9dd2cbcb84c31b1a0322fae2a2137.json"}}], "type": "journal article", "published": "2023-05-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "2709", "issn-l": "2041-1723"}, "abstract": "Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix\u00ae. Here, we dissect disease mechanisms and interactions with environmental triggers in a multi-ethnic sample of 6,073 cases and 84,856 controls. We fine-mapped GWAS signals within HLA (DQ0602, DQB1*03:01 and DPB1*04:02) and discovered seven novel associations (CD207, NAB1, IKZF4-ERBB3, CTSC, DENND1B, SIRPG, PRF1). Significant signals at TRA and DQB1*06:02 loci were found in 245 vaccination-related cases, who also shared polygenic risk. T cell receptor associations in NT1 modulated TRAJ*24, TRAJ*28 and TRBV*4-2 chain-usage. Partitioned heritability and immune cell enrichment analyses found genetic signals to be driven by dendritic and helper T cells. Lastly comorbidity analysis using data from FinnGen, suggests shared effects between NT1 and other autoimmune diseases. NT1 genetic variants shape autoimmunity and response to environmental triggers, including influenza A infection and immunization with Pandemrix\u00ae.", "doi": "10.1038/s41467-023-36120-z", "pmid": "37188663", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10185546"}, {"db": "pii", "key": "10.1038/s41467-023-36120-z"}], "notes": [], "created": "2026-08-21T11:49:20.729Z", "modified": "2026-08-21T11:49:21.875Z"}