{"entity": "publication", "iuid": "4a4c9c8881004c9098441c8e5963dd5b", "timestamp": "2026-08-22T06:57:40.192Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4a4c9c8881004c9098441c8e5963dd5b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4a4c9c8881004c9098441c8e5963dd5b"}}, "title": "Microfluidics platform for studies of peptide - polyelectrolyte interaction.", "authors": [{"family": "Wanselius", "given": "Marcus", "initials": "M"}, {"family": "Searle", "given": "Sean", "initials": "S"}, {"family": "Rodler", "given": "Agnes", "initials": "A"}, {"family": "Tenje", "given": "Maria", "initials": "M"}, {"family": "Abrahms\u00e9n-Alami", "given": "Susanna", "initials": "S"}, {"family": "Hansson", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2022-06-10", "journal": {"title": "Int J Pharm", "issn": "1873-3476", "volume": "621", "pages": "121785", "issn-l": "0378-5173"}, "abstract": "Subcutaneous injection is one of the most common approaches for administering biopharmaceuticals unsuitable for oral delivery. However, there is a lack of methods to predict the behavior of biopharmaceuticals within the extracellular matrix of the subcutaneous tissue. In this work, we present a novel miniaturized microfluidic-based in vitro method able to investigate interactions between drug molecules and the polymers of the subcutaneous extracellular matrix. To validate the method, microgels consisting of, respectively, covalently cross-linked hyaluronic acid, polyacrylic acid, and commercially available DC Bead\u2122, were exposed to three model substances: cytochrome C, protamine sulfate and amitriptyline hydrochloride. These components were chosen to include systems with widely different physiochemical properties (charge, size, self-assembly, etc.) The experimental results were compared with theoretical predictions from a gel model developed earlier. The results show that the method is suitable as a rapid screening method for automated, large-scale, probing of interactions between biopolymers and drug molecules, with small consumption of material.", "doi": "10.1016/j.ijpharm.2022.121785", "pmid": "35500690", "labels": [], "xrefs": [{"db": "pii", "key": "S0378-5173(22)00340-4"}], "notes": [], "created": "2026-08-20T07:57:10.628Z", "modified": "2026-08-20T07:57:10.641Z"}