{"entity": "publication", "iuid": "4407614ca79e4ab3a0090993fcc47f53", "timestamp": "2026-08-20T20:36:19.144Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4407614ca79e4ab3a0090993fcc47f53.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4407614ca79e4ab3a0090993fcc47f53"}}, "title": "Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing.", "authors": [{"family": "Tetzlaff", "given": "Svenja K", "initials": "SK"}, {"family": "Reyhan", "given": "Ekin", "initials": "E"}, {"family": "Layer", "given": "Nikolas", "initials": "N"}, {"family": "Bengtson", "given": "C Peter", "initials": "CP"}, {"family": "Heuer", "given": "Alina", "initials": "A"}, {"family": "Schroers", "given": "Julian", "initials": "J"}, {"family": "Faymonville", "given": "Anton J", "initials": "AJ"}, {"family": "Langeroudi", "given": "Atefeh Pourkhalili", "initials": "AP"}, {"family": "Drewa", "given": "Nina", "initials": "N"}, {"family": "Keifert", "given": "Elijah", "initials": "E"}, {"family": "Wagner", "given": "Julia", "initials": "J"}, {"family": "Soyka", "given": "Stella J", "initials": "SJ"}, {"family": "Schubert", "given": "Marc C", "initials": "MC"}, {"family": "Sivapalan", "given": "Nirosan", "initials": "N"}, {"family": "Pramatarov", "given": "Rangel L", "initials": "RL"}, {"family": "Buchert", "given": "Verena", "initials": "V"}, {"family": "Wageringel", "given": "Tim", "initials": "T"}, {"family": "Grabis", "given": "Elena", "initials": "E"}, {"family": "Wi\u00dfmann", "given": "Niklas", "initials": "N"}, {"family": "Alhalabi", "given": "Obada T", "initials": "OT"}, {"family": "Botz", "given": "Michael", "initials": "M"}, {"family": "Bojcevski", "given": "Jovana", "initials": "J"}, {"family": "Campos", "given": "Joaqu\u00edn", "initials": "J"}, {"family": "Boztepe", "given": "Berin", "initials": "B"}, {"family": "Scheck", "given": "Jonas G", "initials": "JG"}, {"family": "Conic", "given": "Sascha Henry", "initials": "SH"}, {"family": "Puschhof", "given": "Maria C", "initials": "MC"}, {"family": "Villa", "given": "Giulia", "initials": "G"}, {"family": "Drexler", "given": "Richard", "initials": "R"}, {"family": "Zghaibeh", "given": "Yahya", "initials": "Y"}, {"family": "Hausmann", "given": "Fabian", "initials": "F"}, {"family": "H\u00e4nzelmann", "given": "Sonja", "initials": "S"}, {"family": "Karreman", "given": "Matthia A", "initials": "MA"}, {"family": "Kurz", "given": "Felix T", "initials": "FT"}, {"family": "Schr\u00f6ter", "given": "Manuel", "initials": "M"}, {"family": "Thier", "given": "Marc", "initials": "M"}, {"family": "Suwala", "given": "Abigail K", "initials": "AK"}, {"family": "Forsberg-Nilsson", "given": "Karin", "initials": "K"}, {"family": "Acuna", "given": "Claudio", "initials": "C"}, {"family": "Saez-Rodriguez", "given": "Julio", "initials": "J"}, {"family": "Abdollahi", "given": "Amir", "initials": "A"}, {"family": "Sahm", "given": "Felix", "initials": "F"}, {"family": "Breckwoldt", "given": "Michael O", "initials": "MO"}, {"family": "Suchorska", "given": "Bogdana", "initials": "B"}, {"family": "Ricklefs", "given": "Franz L", "initials": "FL"}, {"family": "Heiland", "given": "Dieter Henrik", "initials": "DH"}, {"family": "Venkataramani", "given": "Varun", "initials": "V"}], "type": "journal article", "published": "2025-01-23", "journal": {"title": "Cell", "issn": "1097-4172", "volume": "188", "issue": "2", "pages": "390-411.e36", "issn-l": "0092-8674"}, "abstract": "Glioblastomas are invasive brain tumors with high therapeutic resistance. Neuron-to-glioma synapses have been shown to promote glioblastoma progression. However, a characterization of tumor-connected neurons has been hampered by a lack of technologies. Here, we adapted retrograde tracing using rabies viruses to investigate and manipulate neuron-tumor networks. Glioblastoma rapidly integrated into neural circuits across the brain, engaging in widespread functional communication, with cholinergic neurons driving glioblastoma invasion. We uncovered patient-specific and tumor-cell-state-dependent differences in synaptogenic gene expression associated with neuron-tumor connectivity and subsequent invasiveness. Importantly, radiotherapy enhanced neuron-tumor connectivity by increased neuronal activity. In turn, simultaneous neuronal activity inhibition and radiotherapy showed increased therapeutic effects, indicative of a role for neuron-to-glioma synapses in contributing to therapeutic resistance. Lastly, rabies-mediated genetic ablation of tumor-connected neurons halted glioblastoma progression, offering a viral strategy to tackle glioblastoma. Together, this study provides a framework to comprehensively characterize neuron-tumor networks and target glioblastoma.", "doi": "10.1016/j.cell.2024.11.002", "pmid": "39644898", "labels": [], "xrefs": [{"db": "pii", "key": "S0092-8674(24)01276-5"}], "notes": [], "created": "2026-08-20T06:50:33.482Z", "modified": "2026-08-20T06:50:33.496Z"}