{"entity": "publication", "iuid": "3f9187be588d4d3993945c4bad6af75c", "timestamp": "2026-08-11T08:21:57.944Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3f9187be588d4d3993945c4bad6af75c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3f9187be588d4d3993945c4bad6af75c"}}, "title": "Distribution of adoptively transferred porcine T-lymphoblasts tracked by (18)F-2-fluoro-2-deoxy-D-glucose and position emission tomography.", "authors": [{"family": "Eriksson", "given": "Olof", "initials": "O"}, {"family": "Sadeghi", "given": "Arian", "initials": "A"}, {"family": "Carlsson", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Eich", "given": "Torsten", "initials": "T"}, {"family": "Lundgren", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "T\u00f6tterman", "given": "Thomas", "initials": "T"}, {"family": "Korsgren", "given": "Olle", "initials": "O"}, {"family": "Sundin", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2011-08-00", "journal": {"title": "Nucl. Med. Biol.", "issn": "1872-9614", "volume": "38", "issue": "6", "pages": "827-833", "issn-l": "0969-8051"}, "abstract": "Autologous or allogeneic transfer of tumor-infiltrating T-lymphocytes is a promising treatment for metastatic cancers, but a major concern is the difficulty in evaluating cell trafficking and distribution in adoptive cell therapy. This study presents a method of tracking transfusion of T-lymphoblasts in a porcine model by (18)F-2-fluoro-2-deoxy-d-glucose ([(18)F]FDG) and positron emission tomography.\n\nT-lymphoblasts were labeled with the positron-emitting tracer [(18)F]FDG through incubation. The T-lymphoblasts were administered into the bloodstream, and the distribution was followed by positron emission tomography for 120 min. The cells were administered either intravenously into the internal jugular vein (n=5) or intraarterially into the ascending aorta (n=1). Two of the pigs given intravenous administration were pretreated with low-molecular-weight dextran sulphate.\n\nThe cellular kinetics and distribution were readily quantifiable for up to 120 min. High (78.6% of the administered cells) heterogeneous pulmonary uptake was found after completed intravenous transfusion. The pulmonary uptake was decreased either by preincubating and coadministrating the T-lymphoblasts with low-molecular-weight dextran sulphate or by administrating them intraarterially.\n\nThe present work shows the feasibility of quantitatively monitoring and evaluating cell trafficking and distribution following administration of [(18)F]FDG-labeled T-lymphoblasts. The protocol can potentially be transferred to the clinical setting with few modifications.", "doi": "10.1016/j.nucmedbio.2011.02.011", "pmid": "21843778", "labels": {"Olof Eriksson": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0969-8051(11)00048-5"}], "notes": [], "created": "2020-10-06T14:07:11.070Z", "modified": "2022-11-07T11:35:51.860Z"}