{"entity": "publication", "iuid": "3d23dbd1e2e74c8d87221df257fa700b", "timestamp": "2026-09-25T23:01:32.579Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3d23dbd1e2e74c8d87221df257fa700b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3d23dbd1e2e74c8d87221df257fa700b"}}, "title": "The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals.", "authors": [{"family": "Gong", "given": "Tong", "initials": "T", "orcid": "0000-0002-6887-9432", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/37f9f4ea7a05458f9284267ddfb20c44.json"}}, {"family": "Karlsson", "given": "Robert", "initials": "R", "orcid": "0000-0002-8949-2587", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/620b82d1c76c45dd8d1b131cec3c478c.json"}}, {"family": "Yao", "given": "Shuyang", "initials": "S"}, {"family": "Magnusson", "given": "Patrik K E", "initials": "PKE"}, {"family": "Ajnakina", "given": "Olesya", "initials": "O", "orcid": "0000-0003-3987-1236", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7d6e01ade1044bc98af90b3f982c377f.json"}}, {"family": "Steptoe", "given": "Andrew", "initials": "A", "orcid": "0000-0001-7808-4943", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6860ae61ab249b58ec8c837a2bb76e7.json"}}, {"family": "Bhatta", "given": "Laxmi", "initials": "L"}, {"family": "Brumpton", "given": "Ben", "initials": "B"}, {"family": "Kumar", "given": "Ashish", "initials": "A"}, {"family": "M\u00e9len", "given": "Erik", "initials": "E"}, {"family": "23andMe research team", "given": "", "initials": ""}, {"family": "Lin", "given": "Keng-Han", "initials": "KH"}, {"family": "Tian", "given": "Chao", "initials": "C"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Almqvist", "given": "Catarina", "initials": "C", "orcid": "0000-0002-1045-1898", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/780c252310f449fc96d864b0134aab85.json"}}], "type": "journal article", "published": "2024-08-07", "journal": {"title": "G3", "issn": "2160-1836", "volume": "14", "issue": "8", "issn-l": "2160-1836"}, "abstract": "Dog ownership has been associated with several complex traits, and there is evidence of genetic influence. We performed a genome-wide association study of dog ownership through a meta-analysis of 31,566 Swedish twins in 5 discovery cohorts and an additional 65,986 European-ancestry individuals in 3 replication cohorts from Sweden, Norway, and the United Kingdom. Association tests with >7.4 million single-nucleotide polymorphisms were meta-analyzed using a fixed effect model after controlling for population structure and relatedness. We identified 2 suggestive loci using discovery cohorts, which did not reach genome-wide significance after meta-analysis with replication cohorts. Single-nucleotide polymorphism-based heritability of dog ownership using linkage disequilibrium score regression was estimated at 0.123 (CI 0.038-0.207) using the discovery cohorts and 0.018 (CI -0.002 to 0.039) when adding in replication cohorts. Negative genetic correlation with complex traits including type 2 diabetes, depression, neuroticism, and asthma was only found using discovery summary data. Furthermore, we did not identify any genes/gene-sets reaching even a suggestive level of significance. This genome-wide association study does not, by itself, provide clear evidence on common genetic variants that influence dog ownership among European-ancestry individuals.", "doi": "10.1093/g3journal/jkae116", "pmid": "38820132", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11304603"}, {"db": "pii", "key": "7686067"}, {"db": "figshare", "key": "10.25387/g3.25713189"}], "notes": [], "created": "2026-09-23T13:01:35.777Z", "modified": "2026-09-23T13:01:36.118Z"}