{"entity": "publication", "iuid": "3bfa1e1c05cc46c7bc6d0b110541c650", "timestamp": "2026-09-29T07:07:07.515Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3bfa1e1c05cc46c7bc6d0b110541c650.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3bfa1e1c05cc46c7bc6d0b110541c650"}}, "title": "Ambient air pollution and inflammation-related proteins during early childhood.", "authors": [{"family": "He", "given": "Shizhen", "initials": "S"}, {"family": "Klevebro", "given": "Susanna", "initials": "S"}, {"family": "Baldanzi", "given": "Gabriel", "initials": "G"}, {"family": "Pershagen", "given": "G\u00f6ran", "initials": "G"}, {"family": "Lundberg", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Eneroth", "given": "Kristina", "initials": "K"}, {"family": "Hedman", "given": "Anna M", "initials": "AM"}, {"family": "Andolf", "given": "Ellika", "initials": "E"}, {"family": "Almqvist", "given": "Catarina", "initials": "C"}, {"family": "Bottai", "given": "Matteo", "initials": "M"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Gruzieva", "given": "Olena", "initials": "O"}], "type": "journal article", "published": "2022-12-00", "journal": {"title": "Environ. Res.", "issn": "1096-0953", "volume": "215", "issue": "Pt 2", "pages": "114364", "issn-l": "0013-9351"}, "abstract": "Experimental studies show that short-term exposure to air pollution may alter cytokine concentrations. There is, however, a lack of epidemiological studies evaluating the association between long-term air pollution exposure and inflammation-related proteins in young children. Our objective was to examine whether air pollution exposure is associated with inflammation-related proteins during the first 2 years of life.\n\nIn a pooled analysis of two birth cohorts from Stockholm County (n = 158), plasma levels of 92 systemic inflammation-related proteins were measured by Olink Proseek Multiplex Inflammation panel at 6 months, 1 year and 2 years of age. Time-weighted average exposure to particles with an aerodynamic diameter of <10 \u03bcm (PM10), <2.5 \u03bcm (PM2.5), and nitrogen dioxide (NO2) at residential addresses from birth and onwards was estimated via validated dispersion models. Stratified by sex, longitudinal cross-referenced mixed effect models were applied to estimate the overall effect of preceding air pollution exposure on combined protein levels, \"inflammatory proteome\", over the first 2 years of life, followed by cross-sectional protein-specific bootstrapped quantile regression analysis.\n\nWe identified significant longitudinal associations of inflammatory proteome during the first 2 years of life with preceding PM2.5 exposure, while consistent associations with PM10 and NO2 across ages were only observed among girls. Subsequent protein-specific analyses revealed significant associations of PM10 exposure with an increase in IFN-gamma and IL-12B in boys, and a decrease in IL-8 in girls at different percentiles of proteins levels, at age 6 months. Several inflammation-related proteins were also significantly associated with preceding PM10, PM2.5 and NO2 exposures, at ages 1 and 2 years, in a sex-specific manner.\n\nAmbient air pollution exposure influences inflammation-related protein levels already during early childhood. Our results also suggest age- and sex-specific differences in the impact of air pollution on children's inflammatory profiles.", "doi": "10.1016/j.envres.2022.114364", "pmid": "36126692", "labels": [], "xrefs": [{"db": "pii", "key": "S0013-9351(22)01691-7"}], "notes": [], "created": "2026-09-23T10:00:24.957Z", "modified": "2026-09-23T10:38:09.702Z"}