{"entity": "publication", "iuid": "392f110152f44f59a736469067df64a2", "timestamp": "2026-08-23T09:26:36.775Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/392f110152f44f59a736469067df64a2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/392f110152f44f59a736469067df64a2"}}, "title": "The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study.", "authors": [{"family": "Eriksen", "given": "Rebeca", "initials": "R"}, {"family": "White", "given": "Margaret C", "initials": "MC"}, {"family": "Dawed", "given": "Adem Y", "initials": "AY"}, {"family": "Perez", "given": "Isabel Garcia", "initials": "IG"}, {"family": "Posma", "given": "Joram M", "initials": "JM"}, {"family": "Haid", "given": "Mark", "initials": "M"}, {"family": "Sharma", "given": "Sapna", "initials": "S"}, {"family": "Prehn", "given": "Cornelia", "initials": "C", "orcid": "0000-0002-1274-4715", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c280da18ddda4abb816f6db3dbadc6e9.json"}}, {"family": "Thomas", "given": "E Louise", "initials": "EL"}, {"family": "Koivula", "given": "Robert W", "initials": "RW"}, {"family": "Bizzotto", "given": "Roberto", "initials": "R", "orcid": "0000-0002-8251-1730", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e59c1b67213459d9ade9f1dc87ea865.json"}}, {"family": "Mari", "given": "Andrea", "initials": "A"}, {"family": "Giordano", "given": "Giuseppe N", "initials": "GN"}, {"family": "Pavo", "given": "Imre", "initials": "I"}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM"}, {"family": "De Masi", "given": "Federico", "initials": "F"}, {"family": "Tsirigos", "given": "Konstantinos D", "initials": "KD"}, {"family": "Brunak", "given": "S\u00f8ren", "initials": "S", "orcid": "0000-0003-0316-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/560f89e3ea56424fb96ca55aad9b9814.json"}}, {"family": "Vi\u00f1uela", "given": "Ana", "initials": "A"}, {"family": "Mahajan", "given": "Anubha", "initials": "A"}, {"family": "McDonald", "given": "Timothy J", "initials": "TJ"}, {"family": "Kokkola", "given": "Tarja", "initials": "T"}, {"family": "Rutters", "given": "Femke", "initials": "F"}, {"family": "Beulens", "given": "Joline", "initials": "J"}, {"family": "Muilwijk", "given": "Mirthe", "initials": "M"}, {"family": "Blom", "given": "Marieke", "initials": "M"}, {"family": "Elders", "given": "Petra", "initials": "P"}, {"family": "Hansen", "given": "Tue H", "initials": "TH"}, {"family": "Fernandez-Tajes", "given": "Juan", "initials": "J"}, {"family": "Jones", "given": "Angus", "initials": "A"}, {"family": "Jennison", "given": "Chris", "initials": "C"}, {"family": "Walker", "given": "Mark", "initials": "M"}, {"family": "McCarthy", "given": "Mark I", "initials": "MI"}, {"family": "Pedersen", "given": "Oluf", "initials": "O", "orcid": "0000-0002-3321-3972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0ef37542aea4e67a322b0d6179cd59e.json"}}, {"family": "Ruetten", "given": "Hartmut", "initials": "H"}, {"family": "Forgie", "given": "Ian", "initials": "I"}, {"family": "Holst", "given": "Jens J", "initials": "JJ"}, {"family": "Thomsen", "given": "Henrik S", "initials": "HS"}, {"family": "Ridderstr\u00e5le", "given": "Martin", "initials": "M"}, {"family": "Bell", "given": "Jimmy D", "initials": "JD"}, {"family": "Adamski", "given": "Jerzy", "initials": "J"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Hansen", "given": "Torben", "initials": "T", "orcid": "0000-0001-8748-3831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e9a365eccb44b28b293c7decc6f4b9f.json"}}, {"family": "Holmes", "given": "Elaine", "initials": "E"}, {"family": "Frost", "given": "Gary", "initials": "G", "orcid": "0000-0003-0529-6325", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/894534933d064d1f802f1690ea56f162.json"}}, {"family": "Pearson", "given": "Ewan R", "initials": "ER", "orcid": "0000-0001-9237-8585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e27e9e47f1cc4a969268eb5a65b8045b.json"}}], "type": "journal article", "published": "2024-08-13", "journal": {"title": "J. Clin. Endocrinol. Metab.", "issn": "1945-7197", "volume": "109", "issue": "9", "pages": "e1697-e1707", "issn-l": "0021-972X"}, "abstract": "The role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes (T2D) and obesity is not fully understood.\n\nWe investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D.\n\nWe analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) cohorts, cohort 1 (n = 2127) individuals at risk of diabetes; cohort 2 (n = 789) individuals with new-onset T2D.\n\nOur multiple regression analysis reveals that fasting total GLP-1 is associated with an insulin-resistant phenotype and observe a strong independent relationship with male sex, increased adiposity, and liver fat, particularly in the prediabetes population. In contrast, we showed that incremental GLP-1 decreases with worsening glycemia, higher adiposity, liver fat, male sex, and reduced insulin sensitivity in the prediabetes cohort. Higher fasting total GLP-1 was associated with a low intake of wholegrain, fruit, and vegetables in people with prediabetes, and with a high intake of red meat and alcohol in people with diabetes.\n\nThese studies provide novel insights into the association between fasting and incremental GLP-1, metabolic traits of diabetes and obesity, and dietary intake, and raise intriguing questions regarding the relevance of fasting GLP-1 in the pathophysiology T2D.", "doi": "10.1210/clinem/dgae119", "pmid": "38686701", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11318998"}, {"db": "pii", "key": "7618423"}], "notes": [], "created": "2026-08-21T12:41:55.389Z", "modified": "2026-08-21T12:41:55.475Z"}