{"entity": "publication", "iuid": "34eec251e4f04b88bfdedbaeb8d7369a", "timestamp": "2026-08-20T21:08:25.007Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/34eec251e4f04b88bfdedbaeb8d7369a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/34eec251e4f04b88bfdedbaeb8d7369a"}}, "title": "Molecular atlas of the adult mouse brain.", "authors": [{"family": "Ortiz", "given": "Cantin", "initials": "C", "orcid": "0000-0001-9564-0059", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d0cfad4461f843c4b1671515cfc6beac.json"}}, {"family": "Navarro", "given": "Jose Fernandez", "initials": "JF", "orcid": "0000-0002-4035-5258", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c9e34949eec41deba11bc669e9217b0.json"}}, {"family": "Jurek", "given": "Aleksandra", "initials": "A"}, {"family": "M\u00e4rtin", "given": "Antje", "initials": "A"}, {"family": "Lundeberg", "given": "Joakim", "initials": "J", "orcid": "0000-0003-4313-1601", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9fa47767cd14ef2b9528c8b998cf095.json"}}, {"family": "Meletis", "given": "Konstantinos", "initials": "K", "orcid": "0000-0001-5665-4781", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/314d93feac4048799b81ca9cb04fc078.json"}}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "6", "issue": "26", "pages": "eabb3446", "issn-l": "2375-2548"}, "abstract": "Brain maps are essential for integrating information and interpreting the structure-function relationship of circuits and behavior. We aimed to generate a systematic classification of the adult mouse brain based purely on the unbiased identification of spatially defining features by employing whole-brain spatial transcriptomics. We found that the molecular information was sufficient to deduce the complex and detailed neuroanatomical organization of the brain. The unsupervised (non-expert, data-driven) classification revealed new area- and layer-specific subregions, for example in isocortex and hippocampus, and new subdivisions of striatum. The molecular atlas further supports the characterization of the spatial identity of neurons from their single-cell RNA profile, and provides a resource for annotating the brain using a minimal gene set-a brain palette. In summary, we have established a molecular atlas to formally define the spatial organization of brain regions, including the molecular code for mapping and targeting of discrete neuroanatomical domains.", "doi": "10.1126/sciadv.abb3446", "pmid": "32637622", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7319762"}, {"db": "pii", "key": "abb3446"}], "notes": [], "created": "2026-08-20T11:58:30.986Z", "modified": "2026-08-20T11:58:31.155Z"}