{"entity": "publication", "iuid": "2db21953ea5147d6844d0ad4772bc8fb", "timestamp": "2026-08-23T09:24:38.320Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2db21953ea5147d6844d0ad4772bc8fb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2db21953ea5147d6844d0ad4772bc8fb"}}, "title": "MALT1 inhibition suppresses antigen-specific T cell responses.", "authors": [{"family": "Kerzeli", "given": "Iliana K", "initials": "IK"}, {"family": "Nasi", "given": "Aikaterini", "initials": "A"}, {"family": "Fletcher", "given": "Erika", "initials": "E"}, {"family": "Chourlia", "given": "Aikaterini", "initials": "A"}, {"family": "Kallin", "given": "Anders", "initials": "A"}, {"family": "Finnberg", "given": "Niklas", "initials": "N"}, {"family": "Ersmark", "given": "Karolina", "initials": "K"}, {"family": "Lampinen", "given": "Maria", "initials": "M"}, {"family": "Albertella", "given": "Mark", "initials": "M"}, {"family": "\u00d6berg", "given": "Fredrik", "initials": "F"}, {"family": "Mangsbo", "given": "Sara M", "initials": "SM"}], "type": "journal article", "published": "2024-02-24", "journal": {"title": "Cell Immunol", "issn": "1090-2163", "volume": "397-398", "pages": "104814", "issn-l": null}, "abstract": "The aim of this study was to assess the potential use of a selective small molecule MALT1 inhibitor in solid tumor treatment as an immunotherapy targeting regulatory T-cells (Tregs). In vitro, MALT1 inhibition suppressed the proteolytic cleavage of the MALT1-substrate HOIL1 and blocked IL-2 secretion in Jurkat cells. It selectively suppressed the proliferation of PBMC-derived Tregs, with no effect on conventional CD4+T-cells. In vivo, however, no evident anti-tumor effect was achieved by MALT1 inhibition monotherapy or in combination with anti-CTLA4 in the MB49 cancer model. Despite decreased Treg-frequencies in lymph nodes of tumor-bearing animals, intratumoral Treg depletion was not observed. We also showed that MALT1-inhibition caused a reduction of antigen-specific CD8+T-cells in an adoptive T-cell transfer model. Thus, selective targeting of Tregs would be required to improve the immunotherapeutic effect of MALT1-inhibition. Also, various dosing schedules and combination therapy strategies should be carefully designed and evaluated further.", "doi": "10.1016/j.cellimm.2024.104814", "pmid": "38422979", "labels": [], "xrefs": [{"db": "pii", "key": "S0008-8749(24)00017-0"}], "notes": [], "created": "2026-08-20T06:50:50.523Z", "modified": "2026-08-20T06:50:50.571Z"}