{"entity": "publication", "iuid": "2cd0ff5d430f453ba09b904e68a205a9", "timestamp": "2026-09-08T10:05:24.860Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2cd0ff5d430f453ba09b904e68a205a9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2cd0ff5d430f453ba09b904e68a205a9"}}, "title": "High serum levels of p,p'-DDE are associated with an accelerated decline in GFR during 10 years follow-up.", "authors": [{"family": "Jayasinghe", "given": "Saroj", "initials": "S"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Salihovic", "given": "Samira", "initials": "S"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Lind", "given": "P Monica", "initials": "PM"}], "type": "journal article", "published": "2018-12-10", "journal": {"title": "Sci. Total Environ.", "issn": "1879-1026", "volume": "644", "pages": "371-374", "issn-l": "0048-9697"}, "abstract": "Over the past 20 years, the global incidence of chronic kidney disease (CKD) has been increasing and organochlorine pesticides (such as DDT) is a suspected etiological factor. The present study examines the associations between low level background exposure to p,p'-DDE (1-dichloro-2,2-bis (p-chlorophenyl) ethylene), the main DDT metabolite, and kidney function during a 10-year follow-up. Data was analysed from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (n = 1016, 50% women, all aged 70 years). Serum levels of p,p'-DDE was measured by gas chromatography coupled to high-resolution mass spectrometry (GC/HRMS) at baseline (i.e. age of 70 years). Glomerular filtration rate (GFR) was estimated using serum creatinine and cystatin C at 70, 75 and 80 years of age. A significant decline in GFR was seen during the 10-year follow-up (-24 ml/min/1.73 m2, p < 0.0001). A significant negative interaction was seen between baseline p,p'-DDE levels and change in GFR over time (p < 0.0001) following adjustment for sex, systolic blood pressure, diabetes, BMI, smoking and education level at age 70. Subjects with the lowest levels of p,p'-DDE levels at age 70 showed the lowest decline in GFR over 10 years, while subjects with the highest p,p'-DDE levels showed the greatest decline. Baseline levels of p,p'-DDE were related to an accelerated reduction in GFR over 10 years suggesting a nephrotoxic effect of DDT/p,p'-DDE. These findings support a potential role for DDT in the epidemic of CKD of unknown etiology (CKDu) in agricultural communities of Sri Lanka and Central America where DDT was previously used.", "doi": "10.1016/j.scitotenv.2018.07.020", "pmid": "29981985", "labels": [], "xrefs": [{"db": "pii", "key": "S0048-9697(18)32495-1"}], "notes": [], "created": "2026-08-21T11:28:19.815Z", "modified": "2026-08-21T11:28:19.836Z"}