{"entity": "publication", "iuid": "267e4c40c7e342efbd40438d0246d979", "timestamp": "2026-08-26T22:46:51.379Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/267e4c40c7e342efbd40438d0246d979.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/267e4c40c7e342efbd40438d0246d979"}}, "title": "Transglutaminase 1 and 2 are localized in different blood cells in the freshwater crayfish Pacifastacus leniusculus.", "authors": [{"family": "Junkunlo", "given": "Kingkamon", "initials": "K"}, {"family": "S\u00f6derh\u00e4ll", "given": "Kenneth", "initials": "K"}, {"family": "S\u00f6derh\u00e4ll", "given": "Irene", "initials": "I"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Fish Shellfish Immunol.", "issn": "1095-9947", "volume": "104", "pages": "83-91", "issn-l": "1050-4648"}, "abstract": "In the present study we show that hemocytes in the freshwater crayfish Pacifastacus leniusculus express two different transglutaminases. We describe the sequence of a previously unknown TGase (Pl_TGase1) and named this as Pl_TGase2 and compared this sequence with similar sequences from other crustaceans. The catalytic core domain is similar to the previously described TGase in P. leniusculus, but Pl_TGase2 has significant differences in the N-terminal and C-terminal domains. Further, we show conclusive evidences that these different transglutaminases are specific for different hemocyte types so that Pl_TGase1 is expressed in the hematopoietic tissue and in the cytoplasm of semigranular hemocytes, while Pl_TGase2 is expressed in vesicles in the granular hemocytes. By in situ hybridization we show that both Pl_TGase1 and Pl_TGase2 mRNA are present only in a subset of the respective hemocyte population. This observation indicates that there may be different subtypes of semigranular as well as granular hemocytes which may have different specific functions.", "doi": "10.1016/j.fsi.2020.05.062", "pmid": "32479868", "labels": [], "xrefs": [{"db": "pii", "key": "S1050-4648(20)30388-0"}], "notes": [], "created": "2026-08-21T11:20:02.002Z", "modified": "2026-08-21T11:20:02.015Z"}