{"entity": "publication", "iuid": "239b778e2e954ecf8a5d32bbc4735453", "timestamp": "2026-08-20T20:57:04.802Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/239b778e2e954ecf8a5d32bbc4735453.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/239b778e2e954ecf8a5d32bbc4735453"}}, "title": "SAMHD1 is a barrier to antimetabolite-based cancer therapies.", "authors": [{"family": "Rudd", "given": "Sean G", "initials": "SG", "orcid": "0000-0002-4368-3855", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d65643e96cfe4f3a98cf4f48225eac73.json"}}, {"family": "Schaller", "given": "Torsten", "initials": "T", "orcid": "0000-0001-9597-4112", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/93d3003ec7854be68f4e38283bca1da0.json"}}, {"family": "Herold", "given": "Nikolas", "initials": "N", "orcid": "0000-0001-9468-4543", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/749eedaa5f69414aa315bb875eef9475.json"}}], "type": "journal article", "published": "2017-02-03", "journal": {"title": "Mol Cell Oncol", "issn": "2372-3556", "volume": "4", "issue": "2", "pages": "e1287554", "issn-l": null}, "abstract": "The outcome of acute myelogenous leukemia (AML) therapy depends on the propensity of leukemic blasts to accumulate ara-CTP, the active triphosphate of cytarabine (ara-C). We identified sterile \u03b1 motif and HD domain-containing protein 1 (SAMHD1) as an ara-CTPase that protects cancer cells from cytarabine-induced toxicity. Therefore, we propose targeting SAMHD1 as a strategy to potentiate cytarabine and possibly other antimetabolite-based therapies.", "doi": "10.1080/23723556.2017.1287554", "pmid": "28401188", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5383367"}, {"db": "pii", "key": "1287554"}], "notes": [], "created": "2026-08-20T09:37:44.566Z", "modified": "2026-08-20T09:37:44.676Z"}