{"entity": "publication", "iuid": "20f9306bf098475a95baf13b3a9170d0", "timestamp": "2026-09-30T07:58:51.988Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/20f9306bf098475a95baf13b3a9170d0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/20f9306bf098475a95baf13b3a9170d0"}}, "title": "Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells.", "authors": [{"family": "H\u00fchn", "given": "Daniela", "initials": "D"}, {"family": "Mart\u00ed-Rodrigo", "given": "Pablo", "initials": "P", "orcid": "0000-0002-1049-0918", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c9e68a758664c138149f819e520975e.json"}}, {"family": "Mouron", "given": "Silvana", "initials": "S"}, {"family": "Hansel", "given": "Catherine", "initials": "C"}, {"family": "Tschapalda", "given": "Kirsten", "initials": "K"}, {"family": "Porebski", "given": "Bartlomiej", "initials": "B"}, {"family": "H\u00e4ggblad", "given": "Maria", "initials": "M"}, {"family": "Lidemalm", "given": "Louise", "initials": "L"}, {"family": "Quintela-Fandino", "given": "Miguel", "initials": "M"}, {"family": "Carreras-Puigvert", "given": "Jordi", "initials": "J"}, {"family": "Fernandez-Capetillo", "given": "Oscar", "initials": "O", "orcid": "0000-0002-2690-6885", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ab1f07900e6e466d83763e5fe0020ed6.json"}}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "Mol Oncol", "issn": "1878-0261", "volume": "16", "issue": "1", "pages": "148-165", "issn-l": "1574-7891"}, "abstract": "Among others, expression levels of programmed cell death 1 ligand 1 (PD-L1) have been explored as biomarkers of the response to immune checkpoint inhibitors in cancer therapy. Here, we present the results of a chemical screen that interrogated how medically approved drugs influence PD-L1 expression. As expected, corticosteroids and inhibitors of Janus kinases were among the top PD-L1 downregulators. In addition, we identified that PD-L1 expression is induced by antiestrogenic compounds. Transcriptomic analyses indicate that chronic estrogen receptor alpha (ER\u03b1) inhibition triggers a broad immunosuppressive program in ER-positive breast cancer cells, which is subsequent to their growth arrest and involves the activation of multiple immune checkpoints together with the silencing of the antigen-presenting machinery. Accordingly, estrogen-deprived MCF7 cells are resistant to T-cell-mediated cell killing, in a manner that is independent of PD-L1, but which is reverted by estradiol. Our study reveals that while antiestrogen therapies efficiently limit the growth of ER-positive breast cancer cells, they concomitantly trigger a transcriptional program that favors their immune evasion.", "doi": "10.1002/1878-0261.13083", "pmid": "34392603", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8732350"}], "notes": [], "created": "2026-09-23T10:05:58.708Z", "modified": "2026-09-23T10:05:58.801Z"}