{"entity": "publication", "iuid": "202911f67618416fba6a07164e9d3b59", "timestamp": "2026-08-29T04:24:07.266Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/202911f67618416fba6a07164e9d3b59.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/202911f67618416fba6a07164e9d3b59"}}, "title": "Genetic variants and Expression of Cytochrome p450 Oxidoreductase Predict Postoperative Survival in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma.", "authors": [{"family": "Huang", "given": "Ketuan", "initials": "K"}, {"family": "Liao", "given": "Xiwen", "initials": "X"}, {"family": "Han", "given": "Chuangye", "initials": "C"}, {"family": "Wang", "given": "Xiangkun", "initials": "X"}, {"family": "Yu", "given": "Tingdong", "initials": "T"}, {"family": "Yang", "given": "Chengkun", "initials": "C"}, {"family": "Liu", "given": "Xiaoguang", "initials": "X"}, {"family": "Yu", "given": "Long", "initials": "L"}, {"family": "Chen", "given": "Zhiwei", "initials": "Z"}, {"family": "Qin", "given": "Wei", "initials": "W"}, {"family": "Zhu", "given": "Guangzhi", "initials": "G"}, {"family": "Su", "given": "Hao", "initials": "H"}, {"family": "Liu", "given": "Zhengqian", "initials": "Z"}, {"family": "Zeng", "given": "Xianmin", "initials": "X"}, {"family": "Zhou", "given": "Xin", "initials": "X"}, {"family": "Lu", "given": "Sicong", "initials": "S"}, {"family": "Huang", "given": "Jianlv", "initials": "J"}, {"family": "Liang", "given": "Yu", "initials": "Y"}, {"family": "Liu", "given": "Zhengtao", "initials": "Z"}, {"family": "Deng", "given": "Jianlong", "initials": "J"}, {"family": "Ye", "given": "Xinping", "initials": "X"}, {"family": "Peng", "given": "Tao", "initials": "T"}], "type": "journal article", "published": "2019-02-23", "journal": {"title": "J. Cancer", "issn": "1837-9664", "volume": "10", "issue": "6", "pages": "1453-1465", "issn-l": "1837-9664"}, "abstract": "Our current study investigates the prognostic values of genetic variants and mRNA expression of cytochrome p450 oxidoreductase (POR) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). A total of 19 candidate single nucleotide polymorphisms (SNPs) located in the exons of POR were genotyped using Sanger sequencing from 476 HBV-related HCC patients who underwent hepatectomy between 2003 and 2013. The mRNA expression of POR in 212 patients with HBV-related HCC was obtained from GSE14520 dataset. Survival analysis was performed to investigate the association of POR variants and mRNA expression with overall survival (OS) and recurrence-free survival (RFS). Nomograms were used to predict the prognosis of HBV-related HCC patients. Gene set enrichment analysis (GSEA) was used to investigate the mechanism of POR in HBV-related HCC prognosis. The polymorphism POR-rs1057868 was significantly associated with HBV-related HCC OS (CT/TT vs. CC, hazard ratio [HR] = 0.69, 95% confidence interval [CI] = [0.54, 0.88], P = 0.003), but not significantly associated with RFS (CT/TT vs. CC, P = 0.378). POR mRNA expression was also significantly associated with HBV-related HCC OS (high vs. low, HR = 0.61, 95% CI = [0.38, 0.97], P = 0.036), but not significantly associated with the RFS (high vs. low, P = 0.201). Two nomograms were developed to predict the HBV-related HCC OS. Furthermore, GSEA suggests that multiple gene sets were significantly enriched in liver cancer survival and recurrence, as well as POR-related target therapy in the liver. In conclusion, our study suggests that POR-rs1057868 and mRNA expression may serve as a potential postoperative prognosis biomarker in HBV-related HCC.", "doi": "10.7150/jca.28919", "pmid": "31031855", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6485213"}, {"db": "pii", "key": "jcav10p1453"}], "notes": [], "created": "2026-08-21T13:07:11.076Z", "modified": "2026-08-21T13:07:11.102Z"}