{"entity": "publication", "iuid": "1f42ba2cf1854c0b817a6052a2e40493", "timestamp": "2026-09-26T23:31:03.220Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1f42ba2cf1854c0b817a6052a2e40493.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1f42ba2cf1854c0b817a6052a2e40493"}}, "title": "ERBB3-rs2292239 as primary type 1 diabetes association locus among non-HLA genes in Chinese.", "authors": [{"family": "Sun", "given": "Chengjun", "initials": "C"}, {"family": "Wei", "given": "Haiyan", "initials": "H"}, {"family": "Chen", "given": "Xiuli", "initials": "X"}, {"family": "Zhao", "given": "Zhuhui", "initials": "Z"}, {"family": "Du", "given": "Hongwei", "initials": "H"}, {"family": "Song", "given": "Wenhui", "initials": "W"}, {"family": "Yang", "given": "Yu", "initials": "Y"}, {"family": "Zhang", "given": "Miaoying", "initials": "M"}, {"family": "Lu", "given": "Wei", "initials": "W"}, {"family": "Pei", "given": "Zhou", "initials": "Z"}, {"family": "Xi", "given": "Li", "initials": "L"}, {"family": "Yan", "given": "Jian", "initials": "J"}, {"family": "Zhi", "given": "Dijing", "initials": "D"}, {"family": "Cheng", "given": "Ruoqian", "initials": "R"}, {"family": "Luo", "given": "Feihong", "initials": "F"}], "type": "journal article", "published": "2016-09-00", "journal": {"title": "Meta Gene", "issn": "2214-5400", "volume": "9", "pages": "120-123", "issn-l": null}, "abstract": "Type 1 diabetes (T1D) is an autoimmune disease that has strong contribution of genetic factors to its etiology. We aimed to assess the genetic association between non-HLA genes and T1D in a Chinese case-control cohort recruited from multiple centers consisting of 364 patients with T1D and 719 unrelated healthy children. We genotyped 55 single nucleotide polymorphisms (SNP) markers located in 16 non-HLA genes (VTCN1, PTPN22, CTLA4, SUMO4, CD274, IL2RA, INS, DHCR7, ERBB3, VDR, CYP27B1, CD69, CD276, PTPN2, UBASH3A, and IL2RB) using SNaPshot multiple single-base extension methods. After multivariate analysis and correction for multiple comparisons, we identified the SNP rs2292239 in ERBB3 gene were significantly associated with T1D. The frequency of the major G allele was significantly decreased in patients with T1D (68.8% in T1D vs 77.3% in controls, OR 0.65, 95% CI 0.53-0.79, P = 0.02), and the minor allele T was associated with an increased risk of T1D (OR 1.55, 95% CI 1.26-1.90, P = 0.02). Our haplotype analysis confirmed that rs2292239 was the primary T1D association locus in our current investigation. These results indicated that the ERBB3-rs2292239 was the primary T1D association locus among the investigated 55 SNPs in 16 non-HLA genes in Chinese Han population.", "doi": "10.1016/j.mgene.2016.05.003", "pmid": "27331016", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC4908278"}, {"db": "pii", "key": "S2214-5400(16)30016-0"}], "notes": [], "created": "2026-09-23T12:38:00.376Z", "modified": "2026-09-23T12:38:00.415Z"}