{"entity": "publication", "iuid": "1e9dcbfff67240d1b60a5d4165083882", "timestamp": "2026-08-29T04:16:48.532Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1e9dcbfff67240d1b60a5d4165083882.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1e9dcbfff67240d1b60a5d4165083882"}}, "title": "Changes in Cervical Human Papillomavirus (HPV) Prevalence at a Youth Clinic in Stockholm, Sweden, a Decade After the Introduction of the HPV Vaccine.", "authors": [{"family": "\u00c4hrlund-Richter", "given": "Andreas", "initials": "A"}, {"family": "Cheng", "given": "Liqin", "initials": "L"}, {"family": "Hu", "given": "Yue O O", "initials": "YOO"}, {"family": "Svensson", "given": "Mikaela", "initials": "M"}, {"family": "Pennhag", "given": "Alexandra A L", "initials": "AAL"}, {"family": "Ursu", "given": "Ramona G", "initials": "RG"}, {"family": "Haeggblom", "given": "Linnea", "initials": "L"}, {"family": "Gr\u00fcn", "given": "Nathalie", "initials": "N"}, {"family": "Ramqvist", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Dalianis", "given": "Tina", "initials": "T"}, {"family": "Du", "given": "Juan", "initials": "J"}], "type": "journal article", "published": "2019-03-20", "journal": {"title": "Front. Cell. Infect. Microbiol.", "issn": "2235-2988", "volume": "9", "pages": "59", "issn-l": "2235-2988"}, "abstract": "Aim: This study aimed to follow the impact of human papillomavirus (HPV) catch-up and vaccination on the very high cervical HPV-prevalence in women at a youth clinic in central Stockholm during the period 2008-2018. Background: 2008-2010, cervical HPV-prevalence (69.5%) and HPV16 prevalence (34.7%) were high in non-vaccinated women at a youth clinic in Stockholm. 2013-2015, after the introduction of the quadrivalent-Gardasil\u00ae HPV-vaccine, HPV16 and HPV6 prevalence had decreased. Here, cervical HPV-prevalence was investigated 10 years after primary sampling. Material and Methods: 2017-2018, 178 cervical swabs, from women aged 15-23 years old, were tested for 27 HPV types by a bead-based multiplex method. HPV-prevalence data were then related to vaccination status and age and compared to HPV-prevalence in 615 samples from 2008 to 2010 and 338 samples from 2013 to 2015 from the same clinic, and to HPV types in 143 cervical cancer cases during 2003-2008 in Stockholm. Results: The proportion of vaccinated women increased from 10.7% (2008-2010) to 82.1% (2017-2018). The prevalence of all 27 HPVs, all high-risk HPVs (HR-HPVs) and the combined presence of the quadrivalent-Gardasil\u00ae types HPV16, 18, 6, and 11, was lower in vaccinated compared to unvaccinated women (67.4 vs. 93.3%, p = 0.0031, 60.1 vs. 86.7%, p = 0.0057 and 5.8 vs. 26.7%, p = 0.002, respectively). Furthermore, HPV16 prevalence in non-vaccinated women 2017-2018 was lower than that in 2008-2010 (16.7 and 34.7%, respectively, p = 0.0471) and similar trends were observed for HPV18 and 11. In both vaccinated and non-vaccinated women, the most common non-quadrivalent-Gardasil\u00ae vaccine HR-HPV types were HPV39, 51, 52, 56, and 59. Together they accounted for around 9.8% of cervical cancer cases in Stockholm during 2003-2008, and their prevalence tended to have increased during 2017-2018 compared to 2008-2010. Conclusion: Quadrivalent-Gardasil\u00ae vaccination has decreased HPV-vaccine type prevalence significantly. However, non-vaccine HR-HPV types remain high in potentially high-risk women at a youth clinic in Stockholm.", "doi": "10.3389/fcimb.2019.00059", "pmid": "30949454", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6435486"}], "notes": [], "created": "2026-08-21T12:58:02.972Z", "modified": "2026-08-21T12:58:03.008Z"}