{"entity": "publication", "iuid": "1cc2bb0a25f14bbeae35f48381add2f5", "timestamp": "2026-08-26T22:58:04.731Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1cc2bb0a25f14bbeae35f48381add2f5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1cc2bb0a25f14bbeae35f48381add2f5"}}, "title": "Comparison of vaginal self-sampling and cervical sampling by medical professionals for the detection of HPV and CIN2+: A randomized study.", "authors": [{"family": "Aarnio", "given": "Riina", "initials": "R", "orcid": "0000-0001-6752-531X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60c29c4a11e24b9b9263d5f50ff658be.json"}}, {"family": "Isacson", "given": "Isabella", "initials": "I"}, {"family": "Sanner", "given": "Karin", "initials": "K"}, {"family": "Gustavsson", "given": "Inger", "initials": "I"}, {"family": "Gyllensten", "given": "Ulf", "initials": "U", "orcid": "0000-0002-6316-3355", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eacfdf2095e947e99ac45fe994261b72.json"}}, {"family": "Olovsson", "given": "Matts", "initials": "M"}], "type": "clinical study", "published": "2021-06-15", "journal": {"title": "Int. J. Cancer", "issn": "1097-0215", "volume": "148", "issue": "12", "pages": "3051-3059", "issn-l": "0020-7136"}, "abstract": "Primary screening with human papillomavirus (HPV) test is more effective in reducing cervical cancer incidence than cytology and it also offers the opportunity to self-sample. We conducted a randomized study to compare vaginal self-sampling with cervical sampling by medical professionals for HPV testing concerning prevalence of HPV and detection of cervical intraepithelial neoplasia (CIN) of grade 2 or worse (CIN2+) or grade 3 or worse (CIN3+) in primary screening. In total, 11 951 women aged 30-60 years were randomized into two groups, 5961 for self-sampling (SS arm) and 5990 for sampling by medical professionals (SMP arm). Sampling was performed with a RoversViba-brush in the SS arm and a cytobrush in the SMP arm. All samples were applied to an indicating FTA elute card and analyzed for HPV using a clinically validated real-time PCR test (hpVIR). All HPV-positive women performed repeated sampling about 6 months later using the same procedure as used initially. All HPV-positive women in the second sampling were referred to colposcopy. The prevalence of HPV in the first test did not differ between the SS arm (6.8%, 167/2466) and the SMP arm (7.8%, 118/1519) (P = .255). The prevalence of CIN2+ per 1000 screened women was 17 (43/2466 \u00d7 1000) (95%CI 13-24) in the SS arm and 21 (32/1519 \u00d7 1000) (95%CI 15-30) in the SMP arm. For CIN3+, the prevalence per 1000 screened women was 14 (35/2466 \u00d7 1000) (95%CI 10-20) in the SS arm and 15 (23/1519 \u00d7 1000) (95%CI 10-23) in the SMP arm. In conclusion, self-sampling and sampling by medical professionals showed the same prevalence of HPV and detection rate of CIN2+ and CIN3+ in histology.", "doi": "10.1002/ijc.33482", "pmid": "33497465", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-21T11:02:37.145Z", "modified": "2026-08-21T11:02:37.211Z"}