{"entity": "publication", "iuid": "1cbd88174bb94040ad897cc3f47cc7cb", "timestamp": "2026-08-20T20:49:03.983Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1cbd88174bb94040ad897cc3f47cc7cb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1cbd88174bb94040ad897cc3f47cc7cb"}}, "title": "Trogocytosis of chimeric antigen receptors between T cells is regulated by their transmembrane domains.", "authors": [{"family": "Barbera", "given": "Stefano", "initials": "S", "orcid": "0000-0001-9544-455X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/666ca561c7494caa90336bddf52b4f09.json"}}, {"family": "Schuiling", "given": "Matthijs J A", "initials": "MJA", "orcid": "0009-0005-2049-3601", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/127743eb9ad34ee5915cca1fd3958fef.json"}}, {"family": "Sanjaya", "given": "Nathaniel A", "initials": "NA", "orcid": "0009-0001-8912-9921", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7a0c2cf45419465b9d2d1c5e3677839b.json"}}, {"family": "Pietil\u00e4", "given": "Ilkka", "initials": "I", "orcid": "0000-0001-7398-5769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6056d3fa76c41c6943f50faba0d8cd7.json"}}, {"family": "Sar\u00e9n", "given": "Tina", "initials": "T", "orcid": "0000-0001-5227-6779", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed75a6dcbb9940e49481280af6183d69.json"}}, {"family": "Essand", "given": "Magnus", "initials": "M", "orcid": "0000-0002-9725-0422", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2e56cdd77634c01ab6d98dea8c60430.json"}}, {"family": "Dimberg", "given": "Anna", "initials": "A", "orcid": "0000-0003-4422-9125", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f5d91c4b8784d8081a41604bb3d78d4.json"}}], "type": "journal article", "published": "2025-01-31", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "volume": "10", "issue": "103", "pages": "eado2054", "issn-l": "2470-9468"}, "abstract": "Trogocytosis is an exchange of membrane-associated molecules between cells that can either halt or boost immune responses. However, the mechanism that regulates trogocytosis in T cells and its consequences are not yet clear. Here, we demonstrate that T cells can exchange chimeric antigen receptors (CARs) by trogocytosis, thereby arming recipient T cells with the capacity to respond to tumor antigens by up-regulating proteins associated with a cytotoxic response and killing of target cells. We demonstrate that although trogocytosis is dependent on cell-cell contact, the exchange of a specific cell membrane protein does not require a cognate binding partner on the surface of recipient cells. Instead, the probability that a protein is exchanged by trogocytosis is determined by its transmembrane domain. This finding opens new avenues for modulating this process in CAR-T cells.", "doi": "10.1126/sciimmunol.ado2054", "pmid": "39888980", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T11:59:43.101Z", "modified": "2026-08-20T11:59:43.364Z"}