{"entity": "publication", "iuid": "1c5c56f9d7844c1f81c2cd9f5f432490", "timestamp": "2026-09-30T01:25:59.464Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1c5c56f9d7844c1f81c2cd9f5f432490.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1c5c56f9d7844c1f81c2cd9f5f432490"}}, "title": "Spatial lipidomics reveals brain region-specific changes of sulfatides in an experimental MPTP Parkinson's disease primate model.", "authors": [{"family": "Kaya", "given": "Ibrahim", "initials": "I"}, {"family": "Nilsson", "given": "Anna", "initials": "A"}, {"family": "Lupt\u00e1kov\u00e1", "given": "Dominika", "initials": "D", "orcid": "0000-0002-3691-2584", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c4315e3e4b24bd2a889fa2c82d735a5.json"}}, {"family": "He", "given": "Yachao", "initials": "Y", "orcid": "0000-0002-0241-2901", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dda541fb10974d769b81a896c34c8947.json"}}, {"family": "Vallianatou", "given": "Theodosia", "initials": "T", "orcid": "0000-0002-1477-7756", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4374524ab2c14bd9ae46f904144dea63.json"}}, {"family": "Bj\u00e4rterot", "given": "Patrik", "initials": "P", "orcid": "0000-0002-4350-5530", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a958cde39e9471881c0282f9d62f39c.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "Bezard", "given": "Erwan", "initials": "E", "orcid": "0000-0002-0410-4638", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/92f25ac8ff1d46ce8b68fbd88cd36843.json"}}, {"family": "Andr\u00e9n", "given": "Per E", "initials": "PE", "orcid": "0000-0002-4062-7743", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1dd27e8b238475383983480e10099f6.json"}}], "type": "journal article", "published": "2023-07-26", "journal": {"title": "NPJ Parkinsons Dis", "issn": "2373-8057", "volume": "9", "issue": "1", "pages": "118", "issn-l": null}, "abstract": "Metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to the neurotoxin MPP+ in the brain causes permanent Parkinson's disease-like symptoms by destroying dopaminergic neurons in the pars compacta of the substantia nigra in humans and non-human primates. However, the complete molecular pathology underlying MPTP-induced parkinsonism remains poorly understood. We used dual polarity matrix-assisted laser desorption/ionization mass spectrometry imaging to thoroughly image numerous glycerophospholipids and sphingolipids in coronal brain tissue sections of MPTP-lesioned and control non-human primate brains (Macaca mulatta). The results revealed specific distributions of several sulfatide lipid molecules based on chain-length, number of double bonds, and importantly, hydroxylation stage. More specifically, certain long-chain hydroxylated sulfatides with polyunsaturated chains in the molecular structure were depleted within motor-related brain regions in the MPTP-lesioned animals, e.g., external and internal segments of globus pallidus and substantia nigra pars reticulata. In contrast, certain long-chain non-hydroxylated sulfatides were found to be elevated within the same brain regions. These findings demonstrate region-specific dysregulation of sulfatide metabolism within the MPTP-lesioned macaque brain. The depletion of long-chain hydroxylated sulfatides in the MPTP-induced pathology indicates oxidative stress and oligodendrocyte/myelin damage within the pathologically relevant brain regions. Hence, the presented findings improve our current understanding of the molecular pathology of MPTP-induced parkinsonism within primate brains, and provide a basis for further research regarding the role of dysregulated sulfatide metabolism in PD.", "doi": "10.1038/s41531-023-00558-1", "pmid": "37495571", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10372136"}, {"db": "pii", "key": "10.1038/s41531-023-00558-1"}], "notes": [], "created": "2026-09-23T08:45:57.678Z", "modified": "2026-09-23T08:45:57.833Z"}