{"entity": "publication", "iuid": "1bfc9496f0e14baaa1d77d2380d008b7", "timestamp": "2026-08-22T07:48:17.290Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1bfc9496f0e14baaa1d77d2380d008b7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1bfc9496f0e14baaa1d77d2380d008b7"}}, "title": "A Heparan Sulfate Mimetic RAFT Copolymer Inhibits SARS-CoV-2 Infection and Ameliorates Viral-Induced Inflammation.", "authors": [{"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Guerrini", "given": "Marco", "initials": "M"}, {"family": "Ferro", "given": "Vito", "initials": "V"}, {"family": "Li", "given": "Jin-Ping", "initials": "JP"}, {"family": "Li", "given": "Jinlin", "initials": "J", "orcid": "0000-0002-8998-9278", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef44854e04b441209560929fc2533974.json"}}], "type": "journal article", "published": "2025-02-00", "journal": {"title": "Adv Sci (Weinh)", "issn": "2198-3844", "volume": "12", "issue": "6", "pages": "e2411737", "issn-l": null}, "abstract": "The high transmissibility and mutation ability of coronaviruses enable them to easily escape existing immune protection and also pose a challenge to existing antiviral drugs. Moreover, drugs only targeting viruses cannot always attenuate the \"cytokine storm\". Herein, a synthetic heparan sulfate (HS) mimetic, HMSA-06 is reported, that exhibited antiviral activities against both the SARS-CoV-2 prototype and Omicron strains by targeting viral entry and replication. Of particular note, HMSA-06 demonstrated more potent anti-SARS-CoV-2 effects than PG545 and Roneparstat. SARS-CoV-2 is reported to hijack autophagy to facilitate its replication, therefore boosting autophagy can attenuate SARS-CoV-2 infection. It is revealed that HMSA-06, but not a similar HS mimetic that failed to inhibit SARS-CoV-2, can upregulate cellular autophagy flux. In addition, HMSA-06 was found to robustly block the NLRP3-mediated inflammatory reaction in SARS-CoV-2 infected THP-1 derived macrophages as evidenced by a reduction in inflammasome formation and the subsequent decreased secretion of mature caspase-1 and IL-1\u03b2. The HMSA-06's inflammation inhibitory function is further confirmed using a LPS/ATP-stimulated THP-1 macrophage model. Altogether, this study has identified a promising HS mimetic to combat SARS-CoV-2-associated diseases by inhibiting viral infection and attenuating viral-induced inflammatory reaction, providing insights into the development of novel anti-coronavirus drugs in the future.", "doi": "10.1002/advs.202411737", "pmid": "39679877", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11809384"}], "notes": [], "created": "2026-08-21T10:59:31.453Z", "modified": "2026-08-21T10:59:31.521Z"}