{"entity": "publication", "iuid": "1b45ebfc9b5e452d93c142f7fc789c1c", "timestamp": "2026-08-29T04:22:59.167Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1b45ebfc9b5e452d93c142f7fc789c1c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1b45ebfc9b5e452d93c142f7fc789c1c"}}, "title": "Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair.", "authors": [{"family": "Ma", "given": "Jianhui", "initials": "J"}, {"family": "Benitez", "given": "Jorge A", "initials": "JA"}, {"family": "Li", "given": "Jie", "initials": "J"}, {"family": "Miki", "given": "Shunichiro", "initials": "S"}, {"family": "Ponte de Albuquerque", "given": "Claudio", "initials": "C"}, {"family": "Galatro", "given": "Thais", "initials": "T"}, {"family": "Orellana", "given": "Laura", "initials": "L"}, {"family": "Zanca", "given": "Ciro", "initials": "C"}, {"family": "Reed", "given": "Rachel", "initials": "R"}, {"family": "Boyer", "given": "Antonia", "initials": "A"}, {"family": "Koga", "given": "Tomoyuki", "initials": "T"}, {"family": "Varki", "given": "Nissi M", "initials": "NM"}, {"family": "Fenton", "given": "Tim R", "initials": "TR"}, {"family": "Nagahashi Marie", "given": "Suely Kazue", "initials": "SK"}, {"family": "Lindahl", "given": "Erik", "initials": "E"}, {"family": "Gahman", "given": "Timothy C", "initials": "TC"}, {"family": "Shiau", "given": "Andrew K", "initials": "AK"}, {"family": "Zhou", "given": "Huilin", "initials": "H"}, {"family": "DeGroot", "given": "John", "initials": "J"}, {"family": "Sulman", "given": "Erik P", "initials": "EP"}, {"family": "Cavenee", "given": "Webster K", "initials": "WK"}, {"family": "Kolodner", "given": "Richard D", "initials": "RD"}, {"family": "Chen", "given": "Clark C", "initials": "CC"}, {"family": "Furnari", "given": "Frank B", "initials": "FB"}], "type": "journal article", "published": "2019-03-18", "journal": {"title": "Cancer Cell", "issn": "1878-3686", "volume": "35", "issue": "3", "pages": "504-518.e7", "issn-l": "1535-6108"}, "abstract": "Ionizing radiation (IR) and chemotherapy are standard-of-care treatments for glioblastoma (GBM) patients and both result in DNA damage, however, the clinical efficacy is limited due to therapeutic resistance. We identified a mechanism of such resistance mediated by phosphorylation of PTEN on tyrosine 240 (pY240-PTEN) by FGFR2. pY240-PTEN is rapidly elevated and bound to chromatin through interaction with Ki-67 in response to IR treatment and facilitates the recruitment of RAD51 to promote DNA repair. Blocking Y240 phosphorylation confers radiation sensitivity to tumors and extends survival in GBM preclinical models. Y240F-Pten knockin mice showed radiation sensitivity. These results suggest that FGFR-mediated pY240-PTEN is a key mechanism of radiation resistance and is an actionable target for improving radiotherapy efficacy.", "doi": "10.1016/j.ccell.2019.01.020", "pmid": "30827889", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1520516"}, {"db": "pmc", "key": "PMC6424615"}, {"db": "pii", "key": "S1535-6108(19)30054-6"}], "notes": [], "created": "2026-08-20T06:49:53.094Z", "modified": "2026-08-20T06:49:53.144Z"}