{"entity": "publication", "iuid": "168f8857eecf4bc4a13fd1d4781198c4", "timestamp": "2026-08-25T13:36:02.940Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/168f8857eecf4bc4a13fd1d4781198c4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/168f8857eecf4bc4a13fd1d4781198c4"}}, "title": "Deep characterization of paired chromatin and transcriptomes in four immune cell types from multiple sclerosis patients.", "authors": [{"family": "Fernandes", "given": "Sunjay Jude", "initials": "SJ", "orcid": "0000-0001-5763-0896", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2377a176ec26472a9395540822ab97db.json"}}, {"family": "Ericsson", "given": "Matilda", "initials": "M"}, {"family": "Khademi", "given": "Mohsen", "initials": "M"}, {"family": "Jagodic", "given": "Maja", "initials": "M"}, {"family": "Olsson", "given": "Tomas", "initials": "T"}, {"family": "Gomez-Cabrero", "given": "David", "initials": "D"}, {"family": "Kockum", "given": "Ingrid", "initials": "I"}, {"family": "Tegn\u00e9r", "given": "Jesper", "initials": "J"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Epigenomics", "issn": "1750-192X", "volume": "13", "issue": "20", "pages": "1607-1618", "issn-l": null}, "abstract": "Background: The putative involvement of chromatin states in multiple sclerosis (MS) is thus far unclear. Here we determined the association of chromatin-accessibility with concurrent genetic, epigenetic and transcriptional events. Material & methods: We generated paired assay for transposase-accessible chromatin sequencing and RNA-sequencing profiles from sorted blood immune CD4+ and CD8+ T cells, CD14+ monocytes and CD19+ B cells from healthy controls (HCs) and MS patients. Results: We identified differentially accessible regions between MS patients and HCs, primarily in CD4+ and CD19+. CD4+ regions were enriched for MS-associated single nucleotide polymorphisms and differentially methylated loci. In the vicinity of differentially accessible regions of CD4+ cells, 42 differentially expressed genes were identified. The top two dysregulated genes identified in this multilayer analysis were CCDC114 and SERTAD1. Conclusion: These findings provide new insight into the primary role of CD4+ and CD19+ cells in MS.", "doi": "10.2217/epi-2021-0205", "pmid": "34676774", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-21T12:55:52.989Z", "modified": "2026-08-21T12:55:53.063Z"}