{"entity": "publication", "iuid": "148af1ec35f441efa001b5aff8d8eb25", "timestamp": "2026-08-20T20:28:34.645Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/148af1ec35f441efa001b5aff8d8eb25.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/148af1ec35f441efa001b5aff8d8eb25"}}, "title": "Integrative Modeling Reveals Annexin A2-mediated Epigenetic Control of Mesenchymal Glioblastoma.", "authors": [{"family": "Kling", "given": "Teresia", "initials": "T"}, {"family": "Ferrarese", "given": "Roberto", "initials": "R"}, {"family": "\u00d3 hAil\u00edn", "given": "Darren", "initials": "D"}, {"family": "Johansson", "given": "Patrik", "initials": "P"}, {"family": "Heiland", "given": "Dieter Henrik", "initials": "DH"}, {"family": "Dai", "given": "Fangping", "initials": "F"}, {"family": "Vasilikos", "given": "Ioannis", "initials": "I"}, {"family": "Weyerbrock", "given": "Astrid", "initials": "A"}, {"family": "J\u00f6rnsten", "given": "Rebecka", "initials": "R"}, {"family": "Carro", "given": "Maria Stella", "initials": "MS"}, {"family": "Nelander", "given": "Sven", "initials": "S"}], "type": "journal article", "published": "2016-10-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "volume": "12", "pages": "72-85", "issn-l": "2352-3964"}, "abstract": "Glioblastomas are characterized by transcriptionally distinct subtypes, but despite possible clinical relevance, their regulation remains poorly understood. The commonly used molecular classification systems for GBM all identify a subtype with high expression of mesenchymal marker transcripts, strongly associated with invasive growth. We used a comprehensive data-driven network modeling technique (augmented sparse inverse covariance selection, aSICS) to define separate genomic, epigenetic, and transcriptional regulators of glioblastoma subtypes. Our model identified Annexin A2 (ANXA2) as a novel methylation-controlled positive regulator of the mesenchymal subtype. Subsequent evaluation in two independent cohorts established ANXA2 expression as a prognostic factor that is dependent on ANXA2 promoter methylation. ANXA2 knockdown in primary glioblastoma stem cell-like cultures suppressed known mesenchymal master regulators, and abrogated cell proliferation and invasion. Our results place ANXA2 at the apex of a regulatory cascade that determines glioblastoma mesenchymal transformation and validate aSICS as a general methodology to uncover regulators of cancer subtypes.", "doi": "10.1016/j.ebiom.2016.08.050", "pmid": "27667176", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5078587"}, {"db": "pii", "key": "S2352-3964(16)30407-8"}], "notes": [], "created": "2026-08-20T07:53:53.046Z", "modified": "2026-08-20T07:53:53.060Z"}