{"entity": "publication", "iuid": "10c0f1d6f8c14edc9670234eab95b56a", "timestamp": "2026-09-01T08:32:21.804Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/10c0f1d6f8c14edc9670234eab95b56a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/10c0f1d6f8c14edc9670234eab95b56a"}}, "title": "Endogenous DNA Double-Strand Breaks during DNA Transactions: Emerging Insights and Methods for Genome-Wide Profiling.", "authors": [{"family": "Bouwman", "given": "Britta A M", "initials": "BAM", "orcid": "0000-0002-9827-9497", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26e2947dca1e4467aef5342387c5ca7d.json"}}, {"family": "Crosetto", "given": "Nicola", "initials": "N"}], "type": "journal article", "published": "2018-12-14", "journal": {"title": "Genes (Basel)", "issn": "2073-4425", "volume": "9", "issue": "12", "issn-l": "2073-4425"}, "abstract": "DNA double-strand breaks (DSBs) jeopardize genome integrity and can-when repaired unfaithfully-give rise to structural rearrangements associated with cancer. Exogenous agents such as ionizing radiation or chemotherapy can invoke DSBs, but a vast amount of breakage arises during vital endogenous DNA transactions, such as replication and transcription. Additionally, chromatin looping involved in 3D genome organization and gene regulation is increasingly recognized as a possible contributor to DSB events. In this review, we first discuss insights into the mechanisms of endogenous DSB formation, showcasing the trade-off between essential DNA transactions and the intrinsic challenges that these processes impose on genomic integrity. In the second part, we highlight emerging methods for genome-wide profiling of DSBs, and discuss future directions of research that will help advance our understanding of genome-wide DSB formation and repair.", "doi": "10.3390/genes9120632", "pmid": "30558210", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6316733"}, {"db": "pii", "key": "genes9120632"}], "notes": [], "created": "2026-08-21T13:02:40.689Z", "modified": "2026-08-21T13:02:40.740Z"}