{"entity": "publication", "iuid": "0fe991c582d643de829b1e717f807358", "timestamp": "2026-09-26T23:33:24.983Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0fe991c582d643de829b1e717f807358.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0fe991c582d643de829b1e717f807358"}}, "title": "High-sensitivity cardiac troponin T levels in the emergency department in patients with chest pain but no myocardial infarction.", "authors": [{"family": "Carlsson", "given": "Axel C", "initials": "AC"}, {"family": "Bandstein", "given": "Nadia", "initials": "N"}, {"family": "Roos", "given": "Andreas", "initials": "A"}, {"family": "Hammarsten", "given": "Ola", "initials": "O"}, {"family": "Holzmann", "given": "Martin J", "initials": "MJ"}], "type": "comparative study", "published": "2017-02-01", "journal": {"title": "Int. J. Cardiol.", "issn": "1874-1754", "volume": "228", "pages": "253-259", "issn-l": "0167-5273"}, "abstract": "High-sensitivity cardiac troponin T (hs-cTnT) was recently introduced into clinical practice. The increased sensitivity has decreased the specificity. We aimed to determine the predictors for and prevalence of hs-cTnT levels above the 99th percentile in a stable population of patients without myocardial infarction (MI) who sought medical attention for chest pain in the emergency department.\n\nWe included 11,847 patients with chest pain and at least one hs-cTnT measurement during 2011 and 2012. Patients with any acute reasons for an elevated hs-cTnT level were excluded. We used logistic regression to calculate adjusted odds ratios with 95% confidence intervals for the association between patient characteristics and hs-cTnT levels of >14ng/L. We also determined 50th, 75th, 97.5th, and 99th percentile values of hs-cTnT levels in relation to age, sex, estimated glomerular filtration rate (eGFR), and presence or absence of comorbidities.\n\nIn total, 1360 (11%) patients had hs-cTnT levels of >14ng/L. Men had higher troponin levels than women, and older patients had higher levels than younger patients. The strongest predictor of an elevated troponin level was a reduced eGFR. The 99th percentile for hs-cTnT among all men and among women <50years of age with normal renal function was 20 and 12ng/L, respectively; this level increased to 44 and 36ng/L, respectively, at the age of 70-79years.\n\nA hs-cTnT level above the 99th percentile in patients with chest pain but no MI is common and is related to sex, age, and eGFR.", "doi": "10.1016/j.ijcard.2016.11.087", "pmid": "27865194", "labels": [], "xrefs": [{"db": "pii", "key": "S0167-5273(16)33543-4"}], "notes": [], "created": "2026-09-23T09:47:08.929Z", "modified": "2026-09-23T10:21:19.322Z"}