{"entity": "publication", "iuid": "0c0382eb04ab47e2866f3192570a9880", "timestamp": "2026-09-25T23:04:38.647Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0c0382eb04ab47e2866f3192570a9880.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0c0382eb04ab47e2866f3192570a9880"}}, "title": "Preferences and attitudes regarding early intervention in multiple sclerosis: A systematic literature review.", "authors": [{"family": "Martin", "given": "Sylvia", "initials": "S"}, {"family": "Kihlbom", "given": "Ulrik", "initials": "U"}, {"family": "Pasquini", "given": "Guido", "initials": "G"}, {"family": "Gerli", "given": "Filippo", "initials": "F"}, {"family": "Niccolai", "given": "Claudia", "initials": "C"}, {"family": "Della Bella", "given": "Sara", "initials": "S"}, {"family": "Portaccio", "given": "Emilio", "initials": "E"}, {"family": "Betti", "given": "Matteo", "initials": "M"}, {"family": "Amato", "given": "Maria Pia", "initials": "MP"}, {"family": "Achiron", "given": "Anat", "initials": "A"}, {"family": "Kalron", "given": "Alon", "initials": "A"}, {"family": "Aloni", "given": "Roy", "initials": "R"}, {"family": "Sch\u00f6lin Bywall", "given": "Karin", "initials": "K"}], "type": "systematic review", "published": "2024-12-00", "journal": {"title": "Mult Scler Relat Disord", "issn": "2211-0356", "volume": "92", "pages": "106143", "issn-l": null}, "abstract": "Multiple sclerosis (MS) is a chronic inflammatory disorder affecting the brain and spinal cord, characterized by immune-mediated myelin damage. Early intervention and detection programs have emerged as promising strategies to improve patient outcomes by identifying and treating MS in its earliest stages.\n\nThis systematic literature review aims to provide an overview of the preferences, attitudes, and opinions of both patients and healthcare professionals regarding early intervention or early detection programs for MS.\n\nA comprehensive search strategy was employed in March 2023 across multiple databases (MEDLINE, Scopus, PsyInfo, PubMed), from 1990 to 2023. A total of 38 articles were selected for analysis based on predefined inclusion and exclusion criteria.\n\nThe majority of articles were published in recent years and represented different methods from case reports to randomized controlled trials, with fewer systematic literature reviews. Data collection approaches included patients, healthcare workers, or mixed samples with varying age ranges and gender ratios, frequently preferring women. These samples represented different preference study methods. The included studies were primarily conducted in the USA and the UK. Thematic analysis revealed several key themes : 1) differences emerged between healthcare professionals' and patients' perspectives 2) interventions for MS outside Disease-Modifying Therapies (DMTs) 3) severe side effects 4) communication, information, and knowledge 5) psychological and emotional aspects.\n\nUnderstanding these diverse factors and subgroups within the MS population can inform more effective, personalized approaches to MS prevention and treatment.", "doi": "10.1016/j.msard.2024.106143", "pmid": "39489082", "labels": [], "xrefs": [{"db": "pii", "key": "S2211-0348(24)00719-3"}], "notes": [], "created": "2026-09-23T13:18:04.156Z", "modified": "2026-09-23T13:18:04.189Z"}