{"entity": "publication", "iuid": "09e5480ec42446e9b3e43ec972405797", "timestamp": "2026-05-17T09:22:43.137Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/09e5480ec42446e9b3e43ec972405797.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/09e5480ec42446e9b3e43ec972405797"}}, "title": "Antibodies against the Ebola virus soluble glycoprotein are associated with long-term vaccine-mediated protection of non-human primates.", "authors": [{"family": "Gunn", "given": "Bronwyn M", "initials": "BM"}, {"family": "McNamara", "given": "Ryan P", "initials": "RP"}, {"family": "Wood", "given": "Lianna", "initials": "L"}, {"family": "Taylor", "given": "Sabian", "initials": "S"}, {"family": "Devadhasan", "given": "Anush", "initials": "A"}, {"family": "Guo", "given": "Wenyu", "initials": "W"}, {"family": "Das", "given": "Jishnu", "initials": "J"}, {"family": "Nilsson", "given": "Avlant", "initials": "A", "orcid": "0000-0002-9476-4516", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f2e21dbc1c624f6a841c59e959e948e4.json"}}, {"family": "Shurtleff", "given": "Amy", "initials": "A"}, {"family": "Dubey", "given": "Sheri", "initials": "S"}, {"family": "Eichberg", "given": "Michael", "initials": "M"}, {"family": "Suscovich", "given": "Todd J", "initials": "TJ"}, {"family": "Saphire", "given": "Erica Ollmann", "initials": "EO"}, {"family": "Lauffenburger", "given": "Douglas", "initials": "D", "orcid": "0000-0002-0050-989X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac0a09cb7c9c49de95b660756a4e5464.json"}}, {"family": "Coller", "given": "Beth-Ann", "initials": "B"}, {"family": "Simon", "given": "Jakub K", "initials": "JK"}, {"family": "Alter", "given": "Galit", "initials": "G"}], "type": "journal article", "published": "2023-04-25", "journal": {"title": "Cell Reports", "issn": "2211-1247", "issn-l": null, "volume": "42", "issue": "4", "pages": "112402"}, "abstract": "The 2013 Ebola epidemic in Central and West Africa heralded the emergence of wide-spread, highly pathogenic viruses. The successful recombinant vector vaccine against Ebola (rVSV\u0394G-ZEBOV-GP) will limit future outbreaks, but identifying mechanisms of protection is essential to protect the most vulnerable. Vaccine-induced antibodies are key determinants of vaccine efficacy, yet the mechanism by which vaccine-induced antibodies prevent Ebola infection remains elusive. Here, we exploit a break in long-term vaccine efficacy in non-human primates to identify predictors of protection. Using unbiased humoral profiling that captures neutralization and Fc-mediated functions, we find that antibodies specific for soluble glycoprotein (sGP) drive neutrophil-mediated phagocytosis and predict vaccine-mediated protection. Similarly, we show that protective sGP-specific monoclonal antibodies have elevated neutrophil-mediated phagocytic activity compared with non-protective antibodies, highlighting the importance of sGP in vaccine protection and monoclonal antibody therapeutics against Ebola virus.", "doi": "10.1016/j.celrep.2023.112402", "pmid": "37061918", "labels": {"Avlant Nilsson": null, "DDLS Fellow": null}, "xrefs": [{"db": "mid", "key": "NIHMS1897948"}, {"db": "pmc", "key": "PMC10576837"}, {"db": "pii", "key": "S2211-1247(23)00413-8"}], "notes": [], "created": "2025-03-20T11:10:25.614Z", "modified": "2025-03-21T10:37:39.686Z"}