{"entity": "publication", "iuid": "08d2cf06027647608865c72825664128", "timestamp": "2026-08-22T07:49:19.424Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/08d2cf06027647608865c72825664128.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/08d2cf06027647608865c72825664128"}}, "title": "Extracellular vesicles in heart failure - A study in patients with heart failure with preserved ejection fraction or heart failure with reduced ejection fraction characteristics undergoing elective coronary artery bypass grafting.", "authors": [{"family": "Matan", "given": "Dmitri", "initials": "D"}, {"family": "Mobarrez", "given": "Fariborz", "initials": "F"}, {"family": "L\u00f6fstr\u00f6m", "given": "Ulrika", "initials": "U"}, {"family": "Corbascio", "given": "Matthias", "initials": "M"}, {"family": "Ekstr\u00f6m", "given": "Mattias", "initials": "M"}, {"family": "Hage", "given": "Camilla", "initials": "C"}, {"family": "Lyng\u00e5", "given": "Patrik", "initials": "P"}, {"family": "Persson", "given": "Bengt", "initials": "B"}, {"family": "Eriksson", "given": "Maria", "initials": "M"}, {"family": "Linde", "given": "Cecilia", "initials": "C"}, {"family": "Persson", "given": "Hans", "initials": "H"}, {"family": "Wall\u00e9n", "given": "H\u00e5kan", "initials": "H"}], "type": "journal article", "published": "2022-10-18", "journal": {"title": "Front Cardiovasc Med", "issn": "2297-055X", "volume": "9", "pages": "952974", "issn-l": null}, "abstract": "Extracellular vesicles (EVs) were investigated as potential biomarkers associated with heart failure (HF) pathophysiology in patients undergoing elective coronary artery bypass surgery characterized by HF phenotype.\n\nPatients with preoperative proxy-diagnoses of HF types i.e., preserved (HFpEF; n = 19) or reduced ejection fraction (HFrEF; n = 20) were studied and compared to patients with normal left ventricular function (n = 42). EVs in plasma samples collected from the coronary sinus, an arterial line, and from the right atrium were analyzed by flow cytometry. We studied EVs of presumed cardiomyocyte origin [EVs exposing Connexin-43 + Caveolin-3 (Con43 + Cav3) and Connexin-43 + Troponin T (Con43 + TnT)], of endothelial origin [EVs exposing VE-Cadherin (VE-Cad)] and EVs exposing inflammatory markers [myeloperoxidase (MPO) or pentraxin3 (PTX3)].\n\nMedian concentrations of EVs exposing Con43 + TnT and Con43 + Cav3 were approximately five to six times higher in coronary sinus compared to radial artery indicative of cardiac release. Patients with HFrEF had high trans-coronary gradients of both Con43 + TnT and Con43 + Cav3 EVs, whereas HFpEF had elevated gradients of Con43 + Cav3 EVs but lower gradients of Con43 + TnT. Coronary sinus concentrations of both Con43 + TnT and Con43 + Cav3 correlated significantly with echocardiographic and laboratory measures of HF. MPO-EV concentrations were around two times higher in the right atrium compared to the coronary sinus, and slightly higher in HFpEF than in HFrEF. EV concentrations of endothelial origin (VE-Cad) were similar in all three patient groups.\n\nCon43 + TnT and Con43 + Cav3 EVs are released over the heart indicating cardiomyocyte origin. In HFrEF the EV release profile is indicative of myocardial injury and myocardial stress with elevated trans-coronary gradients of both Con43 + TnT and Con43 + Cav3 EVs, whereas in HFpEF the profile indicates myocardial stress with less myocardial injury.", "doi": "10.3389/fcvm.2022.952974", "pmid": "36330003", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9622760"}], "notes": [], "created": "2026-08-20T13:05:36.884Z", "modified": "2026-08-20T13:05:36.926Z"}