{"entity": "publication", "iuid": "082f6d6572cd45a39861aae297d57fd4", "timestamp": "2026-08-23T22:11:06.083Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/082f6d6572cd45a39861aae297d57fd4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/082f6d6572cd45a39861aae297d57fd4"}}, "title": "Targeting miR-34a/Pdgfra interactions partially corrects alveologenesis in experimental bronchopulmonary dysplasia.", "authors": [{"family": "Ruiz-Camp", "given": "Jordi", "initials": "J"}, {"family": "Quantius", "given": "Jennifer", "initials": "J"}, {"family": "Lignelli", "given": "Ettore", "initials": "E"}, {"family": "Arndt", "given": "Philipp F", "initials": "PF"}, {"family": "Palumbo", "given": "Francesco", "initials": "F"}, {"family": "Nardiello", "given": "Claudio", "initials": "C"}, {"family": "Surate Solaligue", "given": "David E", "initials": "DE"}, {"family": "Sakkas", "given": "Elpidoforos", "initials": "E"}, {"family": "Mi\u017e\u00edkov\u00e1", "given": "Ivana", "initials": "I"}, {"family": "Rodr\u00edguez-Castillo", "given": "Jos\u00e9 Alberto", "initials": "JA"}, {"family": "Vad\u00e1sz", "given": "Istv\u00e1n", "initials": "I"}, {"family": "Richardson", "given": "William D", "initials": "WD"}, {"family": "Ahlbrecht", "given": "Katrin", "initials": "K"}, {"family": "Herold", "given": "Susanne", "initials": "S"}, {"family": "Seeger", "given": "Werner", "initials": "W"}, {"family": "Morty", "given": "Rory E", "initials": "RE", "orcid": "0000-0003-0833-9749", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26760356c3d24c0c98f98035cdc57bad.json"}}], "type": "journal article", "published": "2019-03-00", "journal": {"title": "EMBO Mol Med", "issn": "1757-4684", "volume": "11", "issue": "3", "issn-l": "1757-4676"}, "abstract": "Bronchopulmonary dysplasia (BPD) is a common complication of preterm birth characterized by arrested lung alveolarization, which generates lungs that are incompetent for effective gas exchange. We report here deregulated expression of miR-34a in a hyperoxia-based mouse model of BPD, where miR-34a expression was markedly increased in platelet-derived growth factor receptor (PDGFR)\u03b1-expressing myofibroblasts, a cell type critical for proper lung alveolarization. Global deletion of miR-34a; and inducible, conditional deletion of miR-34a in PDGFR\u03b1+ cells afforded partial protection to the developing lung against hyperoxia-induced perturbations to lung architecture. Pdgfra mRNA was identified as the relevant miR-34a target, and using a target site blocker in vivo, the miR-34a/Pdgfra interaction was validated as a causal actor in arrested lung development. An antimiR directed against miR-34a partially restored PDGFR\u03b1+ myofibroblast abundance and improved lung alveolarization in newborn mice in an experimental BPD model. We present here the first identification of a pathology-relevant microRNA/mRNA target interaction in aberrant lung alveolarization and highlight the translational potential of targeting the miR-34a/Pdgfra interaction to manage arrested lung development associated with preterm birth.", "doi": "10.15252/emmm.201809448", "pmid": "30770339", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6404112"}, {"db": "pii", "key": "emmm.201809448"}], "notes": [], "created": "2026-08-21T12:54:02.474Z", "modified": "2026-08-21T12:54:02.492Z"}