{"entity": "publication", "iuid": "081ec524c925462798f54d544899e3ee", "timestamp": "2026-08-22T08:31:17.623Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/081ec524c925462798f54d544899e3ee.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/081ec524c925462798f54d544899e3ee"}}, "title": "Long non-coding RNAs and TGF-\u03b2 signaling in cancer.", "authors": [{"family": "Papoutsoglou", "given": "Panagiotis", "initials": "P", "orcid": "0000-0003-2115-3500", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/078d1572d1e449548f231a581860ed0a.json"}}, {"family": "Moustakas", "given": "Aristidis", "initials": "A", "orcid": "0000-0001-9131-3827", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f11771bffabf4da6a2a5e2668c7c7c2d.json"}}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Cancer Sci.", "issn": "1349-7006", "volume": "111", "issue": "8", "pages": "2672-2681", "issn-l": "1347-9032"}, "abstract": "Cancer is driven by genetic mutations in oncogenes and tumor suppressor genes and by cellular events that develop a misregulated molecular microenvironment in the growing tumor tissue. The tumor microenvironment is guided by the excessive action of specific cytokines including transforming growth factor-\u03b2 (TGF-\u03b2), which normally controls embryonic development and the homeostasis of young or adult tissues. As a consequence of the genetic alterations generating a given tumor, TGF-\u03b2 can preserve its homeostatic function and attempt to limit neoplastic expansion, whereas, once the tumor has progressed to an aggressive stage, TGF-\u03b2 can synergize with various oncogenic stimuli to facilitate tumor invasiveness and metastasis. TGF-\u03b2 signaling mechanisms via Smad proteins, various ubiquitin ligases, and protein kinases are relatively well understood. Such mechanisms regulate the expression of genes encoding proteins or non-coding RNAs. Among non-coding RNAs, much has been understood regarding the regulation and function of microRNAs, whereas the role of long non-coding RNAs is still emerging. This article emphasizes TGF-\u03b2 signaling mechanisms leading to the regulation of non-coding genes, the function of such non-coding RNAs as regulators of TGF-\u03b2 signaling, and the contribution of these mechanisms in specific hallmarks of cancer.", "doi": "10.1111/cas.14509", "pmid": "32485023", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7419046"}], "notes": [], "created": "2026-08-20T11:17:29.750Z", "modified": "2026-08-20T11:17:29.807Z"}