{"entity": "publication", "iuid": "060d4ede569442488b162a468118e244", "timestamp": "2026-09-01T08:24:56.009Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/060d4ede569442488b162a468118e244.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/060d4ede569442488b162a468118e244"}}, "title": "NUAK1 and NUAK2 Fine-Tune TGF-\u03b2 Signaling.", "authors": [{"family": "van de Vis", "given": "Reinofke A J", "initials": "RAJ"}, {"family": "Moustakas", "given": "Aristidis", "initials": "A", "orcid": "0000-0001-9131-3827", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f11771bffabf4da6a2a5e2668c7c7c2d.json"}}, {"family": "van der Heide", "given": "Lars P", "initials": "LP"}], "type": "journal article", "published": "2021-07-05", "journal": {"title": "Cancers (Basel)", "issn": "2072-6694", "volume": "13", "issue": "13", "issn-l": "2072-6694"}, "abstract": "Transforming growth factor-\u03b2 (TGF-\u03b2) signaling plays a key role in governing various cellular processes, extending from cell proliferation and apoptosis to differentiation and migration. Due to this extensive involvement in the regulation of cellular function, aberrant TGF-\u03b2 signaling is frequently implicated in the formation and progression of tumors. Therefore, a full understanding of the mechanisms of TGF-\u03b2 signaling and its key components will provide valuable insights into how this intricate signaling cascade can shift towards a detrimental course. In this review, we discuss the interplay between TGF-\u03b2 signaling and the AMP-activated protein kinase (AMPK)-related NUAK kinase family. We highlight the function and regulation of these kinases with focus on the pivotal role NUAK1 and NUAK2 play in regulating TGF-\u03b2 signaling. Specifically, TGF-\u03b2 induces the expression of NUAK1 and NUAK2 that regulates TGF-\u03b2 signaling output in an opposite manner. Besides the focus on the TGF-\u03b2 pathway, we also present a broader perspective on the expression and signaling interactions of the NUAK kinases to outline the broader functions of these protein kinases.", "doi": "10.3390/cancers13133377", "pmid": "34282782", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8268639"}, {"db": "pii", "key": "cancers13133377"}], "notes": [], "created": "2026-08-20T13:39:30.864Z", "modified": "2026-08-20T13:39:30.925Z"}