{"entity": "publication", "iuid": "00cd3eeebf664990a06871a4e993b7dd", "timestamp": "2026-08-20T21:08:14.490Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/00cd3eeebf664990a06871a4e993b7dd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/00cd3eeebf664990a06871a4e993b7dd"}}, "title": "A rapid smartphone-based lactate dehydrogenase test for neonatal diagnostics at the point of care.", "authors": [{"family": "Halvorsen", "given": "Cecilia Pegelow", "initials": "CP"}, {"family": "Olson", "given": "Linus", "initials": "L"}, {"family": "Ara\u00fajo", "given": "Ana Catarina", "initials": "AC"}, {"family": "Karlsson", "given": "Mathias", "initials": "M"}, {"family": "Nguy\u1ec5n", "given": "Trang Th\u1ecb", "initials": "TT"}, {"family": "Khu", "given": "Dung T K", "initials": "DTK"}, {"family": "Le", "given": "Ha T T", "initials": "HTT"}, {"family": "Nguy\u1ec5n", "given": "Hoa T B", "initials": "HTB"}, {"family": "Winbladh", "given": "Birger", "initials": "B"}, {"family": "Russom", "given": "Aman", "initials": "A"}], "type": "journal article", "published": "2019-06-26", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "9", "issue": "1", "pages": "9301", "issn-l": "2045-2322"}, "abstract": "There is a growing recognition of the importance of point-of-care tests (POCTs) for detecting critical neonatal illnesses to reduce the mortality rate in newborns, especially in low-income countries, which account for 98 percent of reported neonatal deaths. Lactate dehydrogenase (LDH) is a marker of cellular damage as a result of hypoxia-ischemia in affected organs. Here, we describe and test a POC LDH test direct from whole blood to provide early indication of serious illness in the neonate. The sample-in-result-out POC platform is specifically designed to meet the needs at resource-limited settings. Plasma is separated from whole blood on filter paper with dried-down reagents for colorimetric reaction, combined with software for analysis using a smartphone. The method was clinically tested in newborns in two different settings. In a clinical cohort of newborns of Stockholm (n = 62) and Hanoi (n = 26), the value of R using Pearson's correlation test was 0.91 (p < 0.01) and the R2 = 0.83 between the two methods. The mean LDH (\u00b1SD) for the reference method vs. the POC-LDH was 551 (\u00b1280) U/L and 552 (\u00b1249) U/L respectively, indicating the clinical value of LDH values measured in minutes with the POC was comparable with standardized laboratory analyses.", "doi": "10.1038/s41598-019-45606-0", "pmid": "31243323", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6595069"}, {"db": "pii", "key": "10.1038/s41598-019-45606-0"}], "notes": [], "created": "2026-08-20T09:04:36.420Z", "modified": "2026-08-20T09:04:36.469Z"}